Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Päivi Heikkilä"'
Autor:
Anna K. Nurmi, Liisa M. Pelttari, Johanna I. Kiiski, Sofia Khan, Mika Nurmikolu, Maija Suvanto, Niina Aho, Tiina Tasmuth, Eija Kalso, Johanna Schleutker, Anne Kallioniemi, Päivi Heikkilä, FinnGen, Kristiina Aittomäki, Carl Blomqvist, Heli Nevanlinna
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract In search of novel breast cancer (BC) risk variants, we performed a whole-exome sequencing and variant analysis of 69 Finnish BC patients as well as analysed loss-of-function variants identified in DNA repair genes in the Finns from the Geno
Externí odkaz:
https://doaj.org/article/1ef71f74dbba4df6b950715faf0ce2e8
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-11 (2023)
Abstract Background Much is known about tumor infiltrating lymphocytes (Tils) in primary breast cancer, as this has been the focus of much research in recent years, but regarding recurrent breast cancer, only few studies have been done. Our aim was t
Externí odkaz:
https://doaj.org/article/5070e0ebc007478f974da2850226b8d2
Autor:
Peeter Karihtala, Katja Porvari, Nelli Roininen, Sari Voutilainen, Johanna Mattson, Päivi Heikkilä, Kirsi-Maria Haapasaari, Katri Selander
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-11 (2022)
Abstract The pathophysiology and the optimal treatment of breast neuroendocrine tumours (NETs) are unknown. We compared the mutational profiles of breast NETs (n = 53) with those of 724 publicly available invasive ductal carcinoma (IDC) and 98 pancre
Externí odkaz:
https://doaj.org/article/2af5b7589630403baeb90a0af5c02b58
Autor:
Nimish Godbole, Iiris Nyholm, Maria Hukkinen, Joseph R. Davidson, Athanasios Tyraskis, Jouko Lohi, Päivi Heikkilä, Katja Eloranta, Marjut Pihlajoki, Mark Davenport, Markku Heikinheimo, Antti Kyrönlahti, Mikko P. Pakarinen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Biliary atresia (BA) is a chronic neonatal cholangiopathy characterized by fibroinflammatory bile duct damage. Reliable biomarkers for predicting native liver survival (NLS) following portoenterostomy (PE) surgery are lacking. Herein we expl
Externí odkaz:
https://doaj.org/article/b4d732c72ecb46b58bab43a1c3cef9da
Autor:
Pauliina M. Munne, Lahja Martikainen, Iiris Räty, Kia Bertula, Nonappa, Janika Ruuska, Hanna Ala-Hongisto, Aino Peura, Babette Hollmann, Lilya Euro, Kerim Yavuz, Linda Patrikainen, Maria Salmela, Juho Pokki, Mikko Kivento, Juho Väänänen, Tomi Suomi, Liina Nevalaita, Minna Mutka, Panu Kovanen, Marjut Leidenius, Tuomo Meretoja, Katja Hukkinen, Outi Monni, Jeroen Pouwels, Biswajyoti Sahu, Johanna Mattson, Heikki Joensuu, Päivi Heikkilä, Laura L. Elo, Ciara Metcalfe, Melissa R. Junttila, Olli Ikkala, Juha Klefström
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Reliable luminal estrogen receptor (ERα+) breast cancer models are limited. Here, the authors use patient derived breast epithelial and breast cancer explant cultures grown in several extracellular matrix scaffolds and show that ERα expression is r
Externí odkaz:
https://doaj.org/article/b09c6053c2ba40338196b223c9534247
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Digital services have been found promising in managing different aspects of health, also stress. We developed a web service for cultivating the positive side of stress based on the stress experiences of entrepreneurs. In this pape
Externí odkaz:
https://doaj.org/article/851e556a07a948f290c9fae17c4fde58
Autor:
Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Elevated MYC levels can sensitize tumor cells to apoptosis. In this study, the authors demonstrate that AMPK activation and BCL-2/BCL-XL inhibition have a synergistic effect on apoptosis, and that together with anti PD-1 therapy they can suppress Myc
Externí odkaz:
https://doaj.org/article/d3f1f919795e44fe8702e5ba84a712b6
Publikováno v:
Human Technology, Vol 14, Iss 2, Pp 233-257 (2018)
Stress is typically seen as a negative phenomenon. However, the positive side of stress (i.e., eustress) has the potential to improve well-being, productivity, and innovativeness, thus increasing individuals’ daily resources at work. Focusing on eu
Externí odkaz:
https://doaj.org/article/d8543b0bd5a84ff78b270a59bff3f824
Publikováno v:
Journal of Entrepreneurship, Management and Innovation, Vol 12, Iss 1, Pp 35-55 (2016)
While heavy stress loads seem an unavoidable aspect of entrepreneurship, the positive side of stress (often referred to as ‘eustress’) remains a neglected area of research. This paper contributes to entrepreneurship research by linking the resear
Externí odkaz:
https://doaj.org/article/47d95ea73a8a421cbce79fa631a2602d
Autor:
Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article contained an error in Fig. 7. In panel b, the survival curves were shifted relative to the y axis. This error has been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/be938228d9c14a09b1d43012150cc2cd