Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

Autor: Varela-Eirin, Marta, Varela-Vazquez, Adrian, Guitian-Caamano, Amanda, Paino, Carlos Luis, Mato, Virginia, Largo, Raquel, Aasen, Trond, Tabernero, Arantxa, Fonseca, Eduardo, Kandouz, Mustapha, Caeiro, Jose Ramon, Blanco, Alfonso, Mayan, Maria D.

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regenerat

Externí odkaz: http://arxiv.org/abs/2402.00624

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

Autor: Varela-Eirín, Marta, Varela-Vázquez, Adrián, Guitián-Caamaño, Amanda, Paíno, Carlos Luis, Mato, Virginia, Largo, Raquel, Aasen, Trond, Tabernero, Arantxa, Fonseca, Eduardo, Kandouz, Mustapha, Caeiro, José Ramón, Blanco, Alfonso, Mayán, María D., Universitat Autònoma de Barcelona

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Cell Death & Disease
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
RUC. Repositorio da Universidade da Coruña
instname
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Cell Death and Disease, Vol 9, Iss 12, Pp 1-16 (2018)

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regenerat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44228d922b8219d972bf61bd42643ea1
https://ddd.uab.cat/record/253748

Use of Transduced Adipose Tissue Stromal Cells as Biologic Minipumps to Deliver Levodopa for the Treatment of Neuropathic Pain: Possibilities and Limitations

Autor: Cobacho, Nuria, Serrano, Ana Belén, Casarejos, Maria José, Mena, Mari Angeles, Paíno, Carlos Luis

Publikováno v: Cell Transplantation; December 2009, Vol. 18 Issue: 12 p1341-1358, 18p

Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis.

Autor: Varela-Eirín M; CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, A Coruña, Spain., Carpintero-Fernández P; CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, A Coruña, Spain., Sánchez-Temprano A; CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, A Coruña, Spain., Varela-Vázquez A; CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, A Coruña, Spain., Paíno CL; Neurobiology-Research Service, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain., Casado-Díaz A; UGC Endocrinology and Nutrition, Maimónides Biomedical Research Institute of Córdoba (IMIBIC), Hospital Universitario Reina Sofía - CIBERFES, Universidad de Córdoba, Córdoba, Spain., Calañas-Continente A; UGC Endocrinology and Nutrition, Maimónides Biomedical Research Institute of Córdoba (IMIBIC), Hospital Universitario Reina Sofía - CIBERFES, Universidad de Córdoba, Córdoba, Spain., Mato V; Centre for Medical Informatics and Radiological Diagnosis, Universidade da Coruña, A Coruña, Spain., Fonseca E; CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, A Coruña, Spain., Kandouz M; Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48202, USA., Blanco A; Flow Cytometry Core Technologies, UCD Conway Institute, University College Dublin, Dublin, Ireland., Caeiro JR; Department of Orthopaedic Surgery and Traumatology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Universidade de Santiago de Compostela (USC), Choupana s/n, Santiago de Compostela, Spain., Mayán MD; CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, A Coruña, Spain.

Publikováno v: Aging [Aging (Albany NY)] 2020 Aug 03; Vol. 12 (16), pp. 15882-15905. Date of Electronic Publication: 2020 Aug 03.

Adipose tissue-derived stromal cells (ADSC) express oligodendrocyte and myelin markers, but they do not function as oligodendrocytes.

Autor: Vellosillo L; Servicio de Neurobiología-Investigación, IRYCIS, Hospital Universitario Ramón y Cajal, Carretera de Colmenar km 9, 28034, Madrid, Spain., Muñoz MP; Servicio de Neurobiología-Investigación, IRYCIS, Hospital Universitario Ramón y Cajal, Carretera de Colmenar km 9, 28034, Madrid, Spain., Paíno CL; Servicio de Neurobiología-Investigación, IRYCIS, Hospital Universitario Ramón y Cajal, Carretera de Colmenar km 9, 28034, Madrid, Spain. carlos.paino@hrc.es.

Publikováno v: Histochemistry and cell biology [Histochem Cell Biol] 2017 Nov; Vol. 148 (5), pp. 503-515. Date of Electronic Publication: 2017 Jun 15.