Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Pa, Svingen"'
Publikováno v:
Europe PubMed Central
Farnesyltransferase inhibitors (FTIs) were developed to target abnormal signaling pathways that are commonly activated in neoplastic cells. Five FTIs have recently undergone Phase I testing; and two are currently in Phase II clinical trials. As part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8143406018eb964082f7acba78198fe6
https://pubmed.ncbi.nlm.nih.gov/10873082
https://pubmed.ncbi.nlm.nih.gov/10873082
Publikováno v:
Europe PubMed Central
Flavopiridol, the first potent cyclin-dependent kinase inhibitor to enter clinical trials, was recently found to be cytotoxic to noncycling cells. The present studies were performed to examine the hypothesis that flavopiridol, like several other anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d2cec8dcd8c9730facf637553335fb78
https://pubmed.ncbi.nlm.nih.gov/10811119
https://pubmed.ncbi.nlm.nih.gov/10811119
Publikováno v:
Europe PubMed Central
The tyrphostin AG957 (NSC 654705) inhibits p210bcr/abl, the transforming kinase responsible for most cases of chronic myelogenous leukemia (CML). The present studies were performed to determine the fate of AG957-treated cells and assess the selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eeb86599f1ab3bde341073b064e06a4c
https://pubmed.ncbi.nlm.nih.gov/10656455
https://pubmed.ncbi.nlm.nih.gov/10656455
Publikováno v:
Europe PubMed Central
Bcl-2, Bcl-xL, and Mcl-1 are three related intracellular polypeptides that have been implicated as negative regulators of apoptosis. In contrast, the partner protein Bax acts as a positive regulator of apoptosis. Based on the observation that all fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::90eee7d71c572662e7397d6de5994451
https://pubmed.ncbi.nlm.nih.gov/9446661
https://pubmed.ncbi.nlm.nih.gov/9446661
Autor:
Lm, Martins, Pw, Mesner, Tj, Kottke, Gs, Basi, Sinha S, Js, Tung, Pa, Svingen, Bj, Madden, Takahashi A, Dj, Mccormick, Wc, Earnshaw, Scott Kaufmann
Publikováno v:
Europe PubMed Central
Previous studies have shown that K562 chronic myelogenous leukemia cells are resistant to induction of apoptosis by a variety of agents, including the topoisomerase II (topo II) poison etoposide, when examined 4 to 24 hours after treatment with an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c53f472659c18d5a885e901f3c6d0329
https://pubmed.ncbi.nlm.nih.gov/9373239
https://pubmed.ncbi.nlm.nih.gov/9373239
Autor:
Kc, Bible, Sa, Boerner, Kirkland K, Kl, Anderl, Bartelt D, Pa, Svingen, Tj, Kottke, Yk, Lee, Eckdahl S, Pg, Stalboerger, Rb, Jenkins, Scott Kaufmann
Publikováno v:
Europe PubMed Central
Flavopiridol, the first inhibitor of cyclin-dependent kinases to enter clinical trials, has shown promising antineoplastic activity and is currently undergoing Phase II testing. Little is known about mechanisms of resistance to this agent. In the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::82fe3da395f0d342a671d01704bcb931
http://europepmc.org/abstract/med/10690552
http://europepmc.org/abstract/med/10690552
Publikováno v:
Europe PubMed Central
Phenylacetate (PA) and phenylbutyrate (PB) are aromatic fatty acids that are presently undergoing evaluation as potential antineoplastic agents. In vitro, PA and PB cause differentiation or growth inhibition of malignant cells. Clinical trials of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4d8ce152ab95a8c34157b4cd70257bad
http://europepmc.org/abstract/med/10690554
http://europepmc.org/abstract/med/10690554
Autor:
Pa, Svingen, Je, Karp, Krajewski S, Pw, Mesner, Sd, Gore, Pj, Burke, Jc, Reed, Ya, Lazebnik, Scott Kaufmann
Publikováno v:
Europe PubMed Central
Recent studies have suggested that variations in levels of caspases, a family of intracellular cysteine proteases, can profoundly affect the ability of cells to undergo apoptosis. In this study, immunoblotting was used to examine levels of apoptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b97d701fd85d7a83aecad77be2ded622
http://europepmc.org/abstract/med/11090079
http://europepmc.org/abstract/med/11090079
Publikováno v:
Europe PubMed Central
Topotecan (TPT) is a topoisomerase I (topo I) poison that has shown promising antineoplastic activity in solid tumors and acute leukemia. In the present study, a band depletion assay was used to evaluate the ability of TPT to stabilize topo I-DNA add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::40a8353093335deb7d84a1cf1d6907bc
http://europepmc.org/abstract/med/9058732
http://europepmc.org/abstract/med/9058732
Autor:
Aa, Adjei, Ii, Budihardjo, Ek, Rowinsky, Tj, Kottke, Pa, Svingen, Ca, Buckwalter, Lb, Grochow, Rc, Donehower, Scott Kaufmann
Publikováno v:
Europe PubMed Central
Pyrazoloacridine (PA), an acridine congener that has shown selective toxicity in solid tumor cells, full activity against noncycling and hypoxic cells, and promising activity in a recent Phase I trial, is currently undergoing Phase II testing as a so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f1ea332ef7c5dcc7a56fa6fb696bd103
http://europepmc.org/abstract/med/9815747
http://europepmc.org/abstract/med/9815747