Pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS), a putative P2Y(1) receptor antagonist, blocks signaling at a site distal to the receptor in Madin-Darby canine kidney-D(1) cells

Autor: Shehnaz D, Torres B, María A. Balboa, Pa, Insel

Publikováno v: Europe PubMed Central

Substantial evidence documents the potential importance of P2Y receptor subtypes in the regulation of cellular responses, but few selective antagonists exist for these receptors. In the current study, we assessed the use of pyridoxal-phosphate-6-azop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d06b1b59bcfc102e4e6c4ad89bc4f0f6
https://pubmed.ncbi.nlm.nih.gov/10604969

Colchicine and cytochalasin B enhance cyclic AMP accumulation via postreceptor actions

Autor: Jr, Jasper, Steven Post, Kh, Desai, Pa, Insel, Bernstein D

Publikováno v: Europe PubMed Central

The role of cytoskeletal microtubules and microfilaments in modulating cAMP generation in S49 lymphoma cells was investigated using the agents colchicine and cytochalasin B, respectively, which are known to disrupt these structures. A 1-hr pretreatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::64b1d44ace4899f65f7cc8fed562b044
https://pubmed.ncbi.nlm.nih.gov/7636757

Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors

Autor: Mc, Michel, Jw, Regan, Ma, Gerhardt, Richard Neubig, Pa, Insel, Hj, Motulsky

Publikováno v: Europe PubMed Central

We have recently demonstrated that the alpha 2-adrenergic radioligand [3H]idazoxan also labels additional sites that do not recognize catecholamines but bind with high affinity several chemically distinct drugs previously assumed to be highly selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6c289f3254632cab6880119e356f4c2d
https://pubmed.ncbi.nlm.nih.gov/2153910

Introduction to the Theme "Novel Therapeutics with the Potential to Advance Health Care".

Autor: Insel PA; 1Departments of Pharmacology and Medicine, University of California, San Diego, La Jolla, California, USA; email: pinsel@health.ucsd.edu., Amara SG; 2National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA., Ahluwalia A; 3Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Publikováno v: Annual review of pharmacology and toxicology [Annu Rev Pharmacol Toxicol] 2024 Sep 25. Date of Electronic Publication: 2024 Sep 25.

Ramipril for the Treatment of COVID-19: RAMIC, a Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Autor: Huang DQ; NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, CA, USA.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore., Ajmera V; NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, CA, USA.; Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Tomaszewski C; Department of Emergency Medicine, University of California, San Diego and the El Centro Regional Medical Center, San Diego, CA, USA., LaFree A; Department of Emergency Medicine, University of California, San Diego and the El Centro Regional Medical Center, San Diego, CA, USA., Bettencourt R; NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, CA, USA., Thompson WK; Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA., Smith DM; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Veteran Affairs Medical Center, San Diego, CA, USA., Malhotra A; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Mehta RL; Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Tolia V; Department of Emergency Medicine, University of California San Diego, La Jolla, CA, USA., Yin J; Department of Pharmacy, University of California San Diego, La Jolla, CA, USA., Insel PA; Department of Pharmacology, University of California San Diego, La Jolla, CA, USA.; Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, CA, USA., Leachman S; NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, CA, USA., Jung J; NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, CA, USA., Collier S; Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Richards L; NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, CA, USA., Woods K; Clinical & Translational Research Institute, University of California, San Diego, La Jolla, CA, USA., Amangurbanova M; NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, CA, USA., Bhatt A; Clinical & Translational Research Institute, University of California, San Diego, La Jolla, CA, USA., Zhang X; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health, University of California San Diego, San Diego, CA, USA., Penciu OM; Beverly Hospital, Montebello, CA, USA., Zarich S; Section of Cardiovascular Medicine, Yale New Haven Health Bridgeport Hospital, Bridgeport, CT, USA., Retta T; Department of Internal Medicine, Howard University, Washington, DC, USA., Harkins MS; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Teixeira JP; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Chinnock B; Department of Emergency Medicine, University of California San Francisco-Fresno Medical Education Program, Fresno, CA, USA., Utay NS; Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Lake JE; Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA., Loomba R; NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, CA, USA. roloomba@ucsd.edu.; Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA, USA. roloomba@ucsd.edu.; Division of Epidemiology, Department of Family Medicine and Public Health, University of California at San Diego, San Diego, CA, USA. roloomba@ucsd.edu.

Publikováno v: Advances in therapy [Adv Ther] 2023 Nov; Vol. 40 (11), pp. 4805-4816. Date of Electronic Publication: 2023 Aug 24.