Zobrazeno 1 - 10 of 88 pro vyhledávání: '"Pa, Handford"'
2
Akademický článek
Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation.
Autor: Bo Z; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Rowntree T; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Johnson S; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Nurmahdi H; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Suckling RJ; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Hill J; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Korona B; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Weisshuhn PC; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Sheppard D; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Meng Y; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Liang S; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Lowe ED; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Lea SM; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Electronic address: susan.lea@nih.gov., Redfield C; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address: christina.redfield@bioch.ox.ac.uk., Handford PA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address: penny.handford@bioch.ox.ac.uk.
Publikováno v: Structure (London, England : 1993) [Structure] 2024 Dec 05; Vol. 32 (12), pp. 2325-2336.e5. Date of Electronic Publication: 2024 Nov 01.
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3
Akademický článek
An N-glycan on the C2 domain of JAGGED1 is important for Notch activation.
Autor: Meng Y; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK., Sanlidag S; Faculty for Science and Engineering, Biosciences, Åbo Akademi University, Turku, Finland.; Turku Bioscience Centre, Åbo Akademi University and University of Turku, Turku, Finland., Jensen SA; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK., Burnap SA; Kavli Institute for NanoScience Discovery and Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Struwe WB; Kavli Institute for NanoScience Discovery and Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Larsen AH; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK., Feng X; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK., Mittal S; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK., Sansom MSP; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK., Sahlgren C; Faculty for Science and Engineering, Biosciences, Åbo Akademi University, Turku, Finland.; Turku Bioscience Centre, Åbo Akademi University and University of Turku, Turku, Finland.; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands., Handford PA; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
Publikováno v: Science signaling [Sci Signal] 2022 Oct 11; Vol. 15 (755), pp. eabo3507. Date of Electronic Publication: 2022 Oct 11.
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4
Akademický článek
ELTD1 is present in extracellular vesicles derived from endothelial cells as a cleaved extracellular domain which induces in vivo angiogenesis.
Autor: Sheldon H; Cancer Research UK Molecular Oncology Laboratories Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital Oxford UK., Zhang W; Nuffield Department of Women's & Reproductive Health, Women's Centre University of Oxford John Radcliffe Hospital Oxford UK., Bridges E; Cancer Research UK Molecular Oncology Laboratories Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital Oxford UK., Ang KH; Cancer Research UK Molecular Oncology Laboratories Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital Oxford UK., Lin S; Cancer Research UK Molecular Oncology Laboratories Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital Oxford UK., Masiero M; Nuffield Division of Clinical Laboratory Sciences Radcliffe Department of Medicine John Radcliffe Hospital Oxford UK., Li D; Nuffield Division of Clinical Laboratory Sciences Radcliffe Department of Medicine John Radcliffe Hospital Oxford UK., Handford PA; Department of Biochemistry University of Oxford Oxford UK., Whiteman P; Department of Biochemistry University of Oxford Oxford UK., Fischer R; Nuffield Department of Medicine Target Discovery Institute Oxford University, NDM Research Building Oxford UK., Buffa F; Department of Oncology University of Oxford Churchill Hospital Oxford UK., Vatish M; Nuffield Department of Women's & Reproductive Health, Women's Centre University of Oxford John Radcliffe Hospital Oxford UK., Banham AH; Nuffield Division of Clinical Laboratory Sciences Radcliffe Department of Medicine John Radcliffe Hospital Oxford UK., Harris AL; Cancer Research UK Molecular Oncology Laboratories Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital Oxford UK.
Publikováno v: Journal of extracellular biology [J Extracell Biol] 2022 Aug 02; Vol. 1 (8), pp. e52. Date of Electronic Publication: 2022 Aug 02 (Print Publication: 2022).
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5
Akademický článek
The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling.
Autor: Martins T; Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK., Meng Y; Department of Biochemistry, University of Oxford, Oxford, UK., Korona B; Department of Biochemistry, University of Oxford, Oxford, UK., Suckling R; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Johnson S; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Handford PA; Department of Biochemistry, University of Oxford, Oxford, UK., Lea SM; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Bray SJ; Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK.
Publikováno v: EMBO reports [EMBO Rep] 2021 Oct 05; Vol. 22 (10), pp. e52729. Date of Electronic Publication: 2021 Aug 04.
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7
Akademický článek
Assembly assay identifies a critical region of human fibrillin-1 required for 10-12 nm diameter microfibril biogenesis.
Autor: Jensen SA; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Atwa O; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Handford PA; Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Publikováno v: PloS one [PLoS One] 2021 Mar 18; Vol. 16 (3), pp. e0248532. Date of Electronic Publication: 2021 Mar 18 (Print Publication: 2021).
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8
Akademický článek
A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion.
Autor: Del Cid JS; Department of Cell Biology, University of California San Francisco, San Francisco, California 94158., Reed NI; Department of Cell Biology, University of California San Francisco, San Francisco, California 94158., Molnar K; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94518., Liu S; Department of Cell Biology, University of California San Francisco, San Francisco, California 94158., Dang B; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94518., Jensen SA; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., DeGrado W; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94518., Handford PA; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Sheppard D; Department of Cell Biology, University of California San Francisco, San Francisco, California 94158., Sundaram AB; Department of Cell Biology, University of California San Francisco, San Francisco, California 94158. Electronic address: Aparna.Sundaram@ucsf.edu.
Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Nov 29; Vol. 294 (48), pp. 18232-18243. Date of Electronic Publication: 2019 Oct 22.
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9
Akademický článek
Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy.
Autor: Masiero M; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Li D; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Whiteman P; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Bentley C; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Greig J; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Hassanali T; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Watts S; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Stribbling S; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Yates J; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Bealing E; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Li JL; CRUK Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Chillakuri C; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Sheppard D; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom., Serres S; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom., Sarmiento-Soto M; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom., Larkin J; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom., Sibson NR; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom., Handford PA; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Harris AL; CRUK Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Banham AH; NDCLS, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. alison.banham@ndcls.ox.ac.uk.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2019 Nov; Vol. 18 (11), pp. 2030-2042. Date of Electronic Publication: 2019 Aug 08.
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10
Akademický článek
Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.
Autor: Pfeffer I; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Brewitz L; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Krojer T; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK., Jensen SA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Kochan GT; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK., Kershaw NJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Hewitson KS; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., McNeill LA; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Kramer H; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK., Münzel M; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Hopkinson RJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Oppermann U; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK.; NDORMS, Botnar Research Centre, University of Oxford, Old Road, Oxford, OX3 7LD, UK., Handford PA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., McDonough MA; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Schofield CJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
Publikováno v: Nature communications [Nat Commun] 2019 Oct 28; Vol. 10 (1), pp. 4910. Date of Electronic Publication: 2019 Oct 28.
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