Zobrazeno 1 - 10
of 521
pro vyhledávání: '"PYRONARIDINE"'
Autor:
Alphonse Ouédraogo, Julie Nguyen Ngoc Pouplin, Mavuto Mukaka, Thoopmanee Kaendiao, Andrea Ruecker, Pascal Millet, Thibaut Vallet, Fabrice Ruiz, Sodiomon B. Sirima, Walter R. Taylor
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Primaquine (PQ) has activity against mature P. falciparum gametocytes and proven transmission blocking efficacy (TBE) between humans and mosquitoes. WHO formerly recommended a single transmission blocking dose of 0.75 mg/kg but th
Externí odkaz:
https://doaj.org/article/7d4fb96f16554890974a4f67b93e5a9c
Autor:
Dysoley Lek, Nguon Sokomar, Top Samphornarann, Jeanne Rideout, Saad El-Din Hassan, Tol Bunkea, Saing Sam Ath, Rothpisey Seng, John Hustedt, Thomas J. Peto, Jayme Hughes, Ke Kimmen, Khoy Dy, Bipin Adhikari
Publikováno v:
Tropical Medicine and Health, Vol 52, Iss 1, Pp 1-9 (2024)
Abstract Introduction The national malaria programme of Cambodia targets the rapid elimination of all human malaria by 2025. As clinical cases decline to near-elimination levels, a key strategy is the rapid identification of malaria outbreaks trigger
Externí odkaz:
https://doaj.org/article/a145482b60ce43cabc2a2f16a78e5416
Akademický článek
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Autor:
Michael Ramharter, Abdoulaye A. Djimde, Isabelle Borghini-Fuhrer, Robert Miller, Jangsik Shin, Adam Aspinall, Naomi Richardson, Martina Wibberg, Lawrence Fleckenstein, Sarah Arbe-Barnes, Stephan Duparc
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-18 (2024)
Abstract Background Children are particularly at risk of malaria. This analysis consolidates the clinical data for pyronaridine–artesunate (PA) paediatric granules in children from three randomized clinical trials and a real-world study (CANTAM). M
Externí odkaz:
https://doaj.org/article/c0a0c67d6b674912b88c1f867080b596
Autor:
Shimaa Abd El-Salam El-Sayed, Mohamed Z Sayed-Ahmed, Shaimaa Ahmed Awad Ali, Nourah Alsadaan, Nawazish Alam, Mahmoud S Alkhoudary, Ikuo Igarashi, Mohamed Abdo Rizk
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 3, Pp 93-99 (2024)
Objective: To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in vivo. Methods: Bioinformatic analysis was performed using atom pair fingerprints. An in vitro combination test was
Externí odkaz:
https://doaj.org/article/74e204ef4dec40508fd4ce5b4cba792c
Autor:
Mirjam Groger, Gaston Tona Lutete, Serge-Brice Assi, Jude D. Bigoga, Nsengi Y. Ntamabyaliro, Sarah Arbe-Barnes, Jangsik Shin, Ayola A. Adegnika, Francine Ntoumi, Peter G. Kremsner, Michael Ramharter, Stephan Duparc, Isabelle Borghini-Fuhrer, Ghyslain Mombo-Ngoma
Publikováno v:
International Journal of Infectious Diseases, Vol 137, Iss , Pp 114-117 (2023)
Global health, particularly in underserved settings can benefit immensely from well-trained community health workers (CHWs) supporting primary healthcare interventions. They can reduce morbidity and mortality of infectious diseases like malaria. Dise
Externí odkaz:
https://doaj.org/article/bccdc2d935c8459daa3b85ad7bc4a26a
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6998 (2024)
Even though several new targets (mostly viral infection) for drug repurposing of pyronaridine and artesunate have recently emerged in vitro and in vivo, inter-species pharmacokinetic (PK) data that can extend nonclinical efficacy to humans has not be
Externí odkaz:
https://doaj.org/article/2d2096ac24e74ca3a123535156df3782
Autor:
Mihreteab Alebachew, Woyneshet Gelaye, Megbaru Alemu Abate, Heven Sime, Henok Hailgiorgis, Bokretsion Gidey, Mebrahtom Haile, Gudissa Assefa, Worku Bekele, Habtamu Belay, Jonathan B. Parr, Geremew Tasew, Hussein Mohammed, Ashenafi Assefa
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023)
Abstract Background Early case detection and prompt treatment are important malaria control and elimination strategies. However, the emergence and rapid spread of drug-resistant strains present a major challenge. This study reports the first therapeu
Externí odkaz:
https://doaj.org/article/b90835c0a0124cb7b9789e9b94fb2228
Autor:
Catherine O. Falade, Adebola E. Orimadegun, Fiyinfoluwa I. Olusola, Obaro S. Michael, Oluwafunmibi E. Anjorin, Roland I. Funwei, Aduragbenro D. Adedapo, Abiola L. Olusanya, Bose E. Orimadegun, Olugbenga A. Mokuolu
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-16 (2023)
Abstract Background In Nigeria, declining responsiveness to artemether–lumefantrine (AL), the artemisinin-based combination therapy (ACT) of choice since 2005, has been reported. Pyronaridine–artesunate (PA) is a newer fixed-dose ACT recently pre
Externí odkaz:
https://doaj.org/article/a7485a07faa345a78eed5de9c1ae6fa8
Autor:
Hussein Mohammed, Heven Sime, Henok Hailgiorgis, Melkie Chernet, Mihreteab Alebachew, Hiwot Solomon, Gudissa Assefa, Mebrahtom Haile, Samuel Girma, Worku Bekele, Geremew Tasew, Bokretsion Gidey, Robert J. Commons, Ashenafi Assefa
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-8 (2022)
Abstract Background Declining efficacy of chloroquine for the treatment Plasmodium vivax malaria has been reported in different endemic settings in Ethiopia. This highlights the need to assess alternative options for P. vivax treatment with artemisin
Externí odkaz:
https://doaj.org/article/0afc3756cf994db4bda3a667687b63f6