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Akademický článek

Exploration of influenza A virus PA protein-associated cellular proteins discloses its impact on mitochondrial function

Autor: Chih-Ching Wu, Ee-Hong Tam, Yu-Yin Shih, Yi-Ru Lin, Pei-Chun Hsueh, Hsiang-Yi Shen, Chian-Huey Woung, Li-Ting Wang, Jia-Chen Tsai, Syh-Jae Lin, Chuang-Rung Chang, Po-Yuan Ke, Rei-Lin Kuo

Publikováno v: Virus Research, Vol 345, Iss , Pp 199387- (2024)

Influenza A virus can infect respiratory tracts and may cause severe illness in humans. Proteins encoded by influenza A virus can interact with cellular factors and dysregulate host biological processes to support viral replication and cause pathogen

Externí odkaz: https://doaj.org/article/9ba0d038687f4a3197b3bec5b9583a5e

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Akademický článek

Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

Autor: M. Rufaik Farook, Zack Croxford, Steffan Morgan, Anthony D. Horlock, Amy K. Holt, April Rees, Benjamin J. Jenkins, Carmen Tse, Emma Stanton, D. Mark Davies, Catherine A. Thornton, Nicholas Jones, I. Martin Sheldon, Emma E. Vincent, James G. Cronin

Publikováno v: Molecular Metabolism, Vol 81, Iss , Pp 101900- (2024)

The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients

Externí odkaz: https://doaj.org/article/3288d1dd7df84df79eb03d5700edacb0

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Akademický článek

Novel pyrroline-5-carboxylate reductase 2 (PYCR2) mutation in an Iranian patient with hypomyelinating leukodystrophy: findings of molecular and in silico investigations

Autor: Maryam Akbari, Zeinab Ebrahimi Tapeh, Mona Zaersabet, Hamzeh Rahimi, Maziar Ganji

Publikováno v: Egyptian Journal of Medical Human Genetics, Vol 24, Iss 1, Pp 1-8 (2023)

Abstract Background Hypomyelinating leukodystrophy (HLD) is a specific group of leukodystrophies and is characterized by progressive postnatal growth delay that represents a type of clinically overlapping but genetically heterogeneous diseases with a

Externí odkaz: https://doaj.org/article/0c14ea1f50d0430094279da6f056834f

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Akademický článek

Hypomyelinating Leukodystrophy 10 (HLD10)-Associated Mutations of PYCR2 Form Large Size Mitochondria, Inhibiting Oligodendroglial Cell Morphological Differentiation

Autor: Tomohiro Torii, Remina Shirai, Risa Kiminami, Satoshi Nishino, Takanari Sato, Sui Sawaguchi, Nana Fukushima, Yoichi Seki, Yuki Miyamoto, Junji Yamauchi

Publikováno v: Neurology International, Vol 14, Iss 4, Pp 1062-1080 (2022)

Hypomyelinating leukodystrophy 10 (HLD10) is an autosomal recessive disease related to myelin sheaths in the central nervous system (CNS). In the CNS, myelin sheaths are derived from differentiated plasma membranes of oligodendrocytes (oligodendrogli

Externí odkaz: https://doaj.org/article/73308e4b84da4d5db9643cbc42198219

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Akademický článek

The Prognostic Roles of PYCR2 and ZBTB18 Expression in Tissues of Colorectal Carcinoma and Non-Neoplastic Tissues: An Immunohistochemical Study

Autor: Ola A. Harb, Mariem A. Elfeky, Fady M. Wadea, Ahmed M. Elsayed, Shereen Elshorbagy, Ahmed F. Amin, Ehab M. Oraby, Mohamed Farouk Amin, Abdelwahab S. Almoregy

Publikováno v: Journal of Coloproctology, Vol 42, Iss 03, Pp 193-202 (2022)

Background It is important to detect novel biomarkers responsible for the progression and spread of colorectal cancer (CRC) to better evaluate the prognosis of the patients, provide better management, and foster the development of therapeutic targets

Externí odkaz: https://doaj.org/article/bdb63daa72b647f59dcc62082d50f3b4

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Akademický článek

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Akademický článek

Differential Degradation of TRA2A and PYCR2 Mediated by Ubiquitin E3 Ligase E4B

Autor: Yao Lu, Bo Jiang, Kangli Peng, Shasha Li, Xiangnan Liu, Bufan Wang, Yuntian Chen, Tiepeng Wang, Bo Zhao

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

E4B belongs to the U-box E3 ligase family and functions as either an E3 or an E4 enzyme in protein ubiquitination. Transformer2A (TRA2A) and Pyrroline-5-carboxylate reductase 2 (PYCR2) are related to cancer development and are overexpressed in many c

Externí odkaz: https://doaj.org/article/9e8f4d9f84c44299965c180dfeaf9227

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Akademický článek

PYCR in Kidney Renal Papillary Cell Carcinoma: Expression, Prognosis, Gene Regulation Network, and Regulation Targets

Autor: Zheng Shao, Lingling Lu, Yongshi Cui, Li Deng, Qinying Xu, Quanyan Liang, Xiaoyong Lu, Juying Zhang, Jv Chen, Yongli Situ

Publikováno v: Frontiers in Bioscience-Landmark, Vol 27, Iss 12, p 336 (2022)

Background: Pyrroline-5-carboxylate reductase (PYCR) includes three human genes encoding three isozymes, PYCR1, PYCR2, and PYCR3 (or PYCRL), which facilitate the final step in the conversion of glutamine to proline. These genes play important roles i

Externí odkaz: https://doaj.org/article/f1e1113fa8d14c24967f2b6cbf2b8509

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