Zobrazeno 1 - 10
of 2 517
pro vyhledávání: '"PXR"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116994- (2024)
Background: Myocardial infarction (MI) has emerged as the primary cause of global mortality. Managing blood sugar levels could play a vital role in the treatment of MI. Dapagliflozin (DPG), a commonly used hypoglycemic drug, has demonstrated efficacy
Externí odkaz:
https://doaj.org/article/fad72f7f8aae41b4a3d3e6185290d6b8
Akademický článek
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Autor:
Rebecca R. Florke Gee, Andrew D. Huber, Jing Wu, Richa Bajpai, Allister J. Loughran, Shondra M. Pruett-Miller, Taosheng Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 11, Pp 4523-4534 (2023)
Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [e.g., cytochrome P450 3A4 (CYP3A4)] and transporters. Although the regulation of PXR target genes is well-characterized, le
Externí odkaz:
https://doaj.org/article/5971bd48286446cb86209bac424bd79b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Cells, Vol 13, Iss 8, p 681 (2024)
This review explores the likely clinical impact of Pregnane X Receptor (PXR) activation by vitamin K on human health. PXR, initially recognized as a master regulator of xenobiotic metabolism in liver, emerges as a key regulator influencing intestinal
Externí odkaz:
https://doaj.org/article/cd1e60c8f2214a1585b1ca8d89e4d8b3
Publikováno v:
Alʹmanah Kliničeskoj Mediciny, Vol 51, Iss 1, Pp 1-13 (2023)
Aim: To summarize the state-of-the-art data on the molecular mechanisms of bile acid (BA) synthesis and absorption, their impaired absorption and receptor-dependent signaling, as well as on the effects of the gut microbiota on BA metabolism in inflam
Externí odkaz:
https://doaj.org/article/0722b5abd4e448d493e75059352c32df
EXPRESSION OF PXR, MDR1, CYP3A5, AND CYP2B6 IN HIGH-GRADE SEROUS OVARIAN CANCER AND ITS SIGNIFICANCE
Autor:
ZHANG Ping, MA Lan, CHEN Hua
Publikováno v:
精准医学杂志, Vol 38, Iss 2, Pp 135-139 (2023)
Objective To investigate the expression and significance of progesterone X receptor (PXR), multidrug resistant protein 1 (MDR1), cytochrome P450 3A5 (CYP3A5), and cytochrome P450 2B6 (CYP2B6) in high-grade serous ovarian cancer (HGSOC). Methods A tot
Externí odkaz:
https://doaj.org/article/f97394880c324379b0bec3b7026def0d
Autor:
Mikko Karpale, Outi Kummu, Olli Kärkkäinen, Marko Lehtonen, Juha Näpänkangas, Uta M. Herfurth, Albert Braeuning, Jaana Rysä, Jukka Hakkola
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101779- (2023)
Objective: Both obesity and exposure to chemicals may induce non-alcoholic fatty liver disease (NAFLD). Pregnane X Receptor (PXR) is a central target of metabolism disrupting chemicals and disturbs hepatic glucose and lipid metabolism. We hypothesize
Externí odkaz:
https://doaj.org/article/32ce7750be6c491e94cf9ff4206bfded
Autor:
Elaheh Jabbari Hagh, Ali Mousavi, Seyyedeh Mina Hejazian, Mehdi Haghi, Samaneh Esfahanian, Elham Ahmadian, Sepideh Zununi Vahed, Mohammadreza Ardalan
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 13, Iss 2, Pp 393-398 (2023)
Purpose: Calcineurin inhibitors (CNIs) such as tacrolimus are a major immunosuppressive therapy after renal transplantation, which inhibit cytokine expression. The pharmacokinetics of such drugs is influenced by cytochrome P450 (CYP) enzymes, multi-d
Externí odkaz:
https://doaj.org/article/d80415188bcb459e8716105cb772ee88
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 1, Pp 63-71 (2023)
Background and Aims: Barrett's esophagus (BE) is the precursor lesion for esophageal adenocarcinoma (EAC). To detect EAC in early stage, patients with BE undergo endoscopic surveillance. Surveillance cohorts largely consist of nondysplastic BE (NDBE)
Externí odkaz:
https://doaj.org/article/563805a5ea2341f2a536fad0b654e164