Evidence that cholesteryl ester and triglyceride accumulation in J774 macrophages induced by very low density lipoprotein subfractions occurs by different mechanisms

Autor: AJ Evans, CG Sawyez, BM Wolfe, PW Connelly, GF Maguire, MW Huff

Publikováno v: Journal of Lipid Research, Vol 34, Iss 5, Pp 703-717 (1993)

The present investigations have examined the mechanism(s) whereby Sf 60-400 very low density lipoproteins (VLDL) from Type IV hypertriglyceridemic subjects cause cholesteryl ester and triglyceride accumulation in J774 macrophages. Both apolipoprotein

Externí odkaz: https://doaj.org/article/ed9c4b631ff84b9094dbc14306e65b72

Identification and metabolic characteristics of an apolipoprotein C-II variant isolated from a hypertriglyceridemic subject.

Autor: MW Huff, AJ Evans, BM Wolfe, PW Connelly, GF Maguire, WL Strong

Publikováno v: Journal of Lipid Research, Vol 31, Iss 3, Pp 385-396 (1990)

The very low density lipoprotein (VLDL) apolipoproteins from a Type IV hypertriglyceridemic Caucasian subject (plasma TG: 645 mg/dl) and his brother (plasma TG: 328 mg/dl) were separated by isoelectric focusing gel electrophoresis (IEF) and found to

Externí odkaz: https://doaj.org/article/623305201c104d4f9f316b1efcff596f

Omega-3 Polyunsaturated Fatty Acids with Adipose Tissue Inflammation: Longitudinal Analysis in the PROMISE Cohort.

Autor: Chon JE; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Semnani-Azad Z; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Lai KZH; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Connelly PW; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Retnakaran R; Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada., Harris SB; Department of Family Medicine, Western University, London, Ontario, Canada., Metherel AH; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Jenkins DJA; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada., Bazinet RP; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Hanley AJ; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada.; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Jun 29. Date of Electronic Publication: 2024 Jun 29.

Postpartum weight retention and the early evolution of cardiovascular risk over the first 5 years after pregnancy.

Autor: Kramer CK; Leadership Sinai Centre for Diabetes, University of Toronto, Mount Sinai Hospital, 60 Murray Street, Suite L5-025, Mailbox-21, Toronto, ON, M5T 3L9, Canada.; Division of Endocrinology, University of Toronto, Toronto, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada., Ye C; Leadership Sinai Centre for Diabetes, University of Toronto, Mount Sinai Hospital, 60 Murray Street, Suite L5-025, Mailbox-21, Toronto, ON, M5T 3L9, Canada., Hanley AJ; Leadership Sinai Centre for Diabetes, University of Toronto, Mount Sinai Hospital, 60 Murray Street, Suite L5-025, Mailbox-21, Toronto, ON, M5T 3L9, Canada.; Division of Endocrinology, University of Toronto, Toronto, Canada.; Department of Nutritional Sciences, University of Toronto, Toronto, Canada., Connelly PW; Division of Endocrinology, University of Toronto, Toronto, Canada.; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada., Sermer M; Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, Canada., Zinman B; Leadership Sinai Centre for Diabetes, University of Toronto, Mount Sinai Hospital, 60 Murray Street, Suite L5-025, Mailbox-21, Toronto, ON, M5T 3L9, Canada.; Division of Endocrinology, University of Toronto, Toronto, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada., Retnakaran R; Leadership Sinai Centre for Diabetes, University of Toronto, Mount Sinai Hospital, 60 Murray Street, Suite L5-025, Mailbox-21, Toronto, ON, M5T 3L9, Canada. Ravi.Retnakaran@sinaihealth.ca.; Division of Endocrinology, University of Toronto, Toronto, Canada. Ravi.Retnakaran@sinaihealth.ca.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Ravi.Retnakaran@sinaihealth.ca.

Publikováno v: Cardiovascular diabetology [Cardiovasc Diabetol] 2024 Mar 18; Vol. 23 (1), pp. 101. Date of Electronic Publication: 2024 Mar 18.

Deteriorating beta cell function is the dominant determinant of progression from normal glucose tolerance to prediabetes/diabetes in young women following pregnancy.

Autor: Retnakaran R; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada. Ravi.Retnakaran@sinaihealth.ca.; Division of Endocrinology, University of Toronto, Toronto, ON, Canada. Ravi.Retnakaran@sinaihealth.ca.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. Ravi.Retnakaran@sinaihealth.ca., Ye C; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada., Kramer CK; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada.; Division of Endocrinology, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Hanley AJ; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada.; Division of Endocrinology, University of Toronto, Toronto, ON, Canada.; Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada., Connelly PW; Division of Endocrinology, University of Toronto, Toronto, ON, Canada.; Keenan Research Centre for Biomedical Science of St Michael's Hospital, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Sermer M; Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, ON, Canada., Zinman B; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada.; Division of Endocrinology, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Publikováno v: Diabetologia [Diabetologia] 2023 Nov; Vol. 66 (11), pp. 2154-2163. Date of Electronic Publication: 2023 Aug 24.