Contribution of Puma to Inflammatory Resolution During Early Pneumococcal Pneumonia

Autor: Daniel E. Kennedy II, Perceus Mody, Jean-Francois Gout, Wei Tan, Keun Seok Seo, Alicia K. Olivier, Jason W. Rosch, Justin A. Thornton

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Apoptosis of cells at the site of infection is a requirement for shutdown of inflammatory signaling, avoiding tissue damage, and preventing progression of sepsis. Puma+/+ and Puma-/- mice were challenged with TIGR4 strain pneumococcus and cytokines w

Externí odkaz: https://doaj.org/article/393bb0a9aa2c4a2980f87ebaa51cbb8e

Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains

Autor: Vennu Narendar, Philippe Juin, A. K. D. Bhavani, Rémy Le Guével, Fabien Gautier, Appala Venkata Ramana Murthy, Nicolas Levoin, Nangunoori Sampath Kumar, René Grée, Chada Raji Reddy, Paul Mosset, Hélène Solhi, Pasula Aparna, Julie Roul

Publikováno v: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2021, 52, pp.128390. ⟨10.1016/j.bmcl.2021.128390⟩

International audience; A small library of new piperidine-triazole hybrids with 3-aryl isoxazole side chains has been designed and synthesized. Their cytotoxicity against a panel of seven cancer cell lines has been established. For the most promising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae63b759b6b3265e31ade8013c76432d
https://hal.archives-ouvertes.fr/hal-03414697/document

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STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392

Autor: Yanghua Qin, Feng Ma, Fan Zhang, Jingfei Zhu, Lifen Xie, Sudan He, Dapei Li, Zigang Qiao, Liang Li, Fangrong Shen, Shengchuan Chen, Sanyue Mai, Haiping Yao

Publikováno v: The Journal of Biological Chemistry

Interferon-γ-inducible factor 16 (IFI16) triggers stimulator of interferon (IFN) genes (STING)-dependent type I IFN production during host antiviral immunity and facilitates p53-dependent apoptosis during suppressing tumorigenesis. We have previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4a9b5105bfc9cd2960efbb8c871a94
https://doi.org/10.1016/j.jbc.2021.100930

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

Autor: Mollereau, B., Rzechorzek, N. M., Roussel, B. D., Sedru, M., Brink, D., Bailly-Maitre, B., Palladino, F., Medinas, D. B., Domingos, P. M., Hunot, S., Chandran, S., Birman, S., Baron, T., Vivien, D., Duarte, C. B., Ryoo, H. D., Steller, H., Urano, F., Chevet, E., Kroemer, G., Ciechanover, A., Calabrese, E. J., Kaufman, R. J., Hetz, C

Publikováno v: Brain Research
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. 〈10.1016/j.brainres.2016.02.033〉
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. ⟨10.1016/j.brainres.2016.02.033⟩
Mollereau, B, Rzechorzek, N M, Roussel, BD, Sedru, M, Van denBrink, D, Bailly-Maitre, B, Palladino, F, Medinas, DB, Domingos, PM, Hunot, S, Chandran, S, Birman, S, Baron, T, Vivien, D, Duarte, CB, Ryoo, HD, Steller, H, Urano, F, Chevet, E, Kroemer, G, Ciechanover, A, Calabrese, EJ, Kaufman, RJ & Hetz, C 2016, ' Adaptive preconditioning in neurological diseases-­ therapeutic insights from proteostatic perturbations ', Brain Research . https://doi.org/10.1016/j.brainres.2016.02.033

In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac2c955da4a10f0f472d98f9cd8189b5
http://europepmc.org/articles/PMC5010532