Zobrazeno 1 - 10
of 37
pro vyhledávání: '"PTM, posttranslational modification"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 599-608 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 599-608 (2021)
Redox-altered plasticity refers to redox-dependent reversible changes in synaptic plasticity via altering functions of key proteins, such as N-methyl-d-aspartate receptor (NMDAR). Age-related cognitive disorders includes Alzheimer's disease (AD), vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21b63fdf19c7ae5028af59b5579ddfe
http://europepmc.org/articles/PMC7982492
http://europepmc.org/articles/PMC7982492
Autor:
Benjamin C. Blum, Weiwei Lin, Matthew L. Lawton, Qian Liu, Julian Kwan, Isabella Turcinovic, Ryan Hekman, Pingzhao Hu, Andrew Emili
Publikováno v:
Molecular & Cellular Proteomics : MCP
Metabolism is recognized as an important driver of cancer progression and other complex diseases, but global metabolite profiling remains a challenge. Protein expression profiling is often a poor proxy since existing pathway enrichment models provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d41bf9df796960e736363aaca606dd
http://europepmc.org/articles/PMC8761777
http://europepmc.org/articles/PMC8761777
Autor:
Claus Garbe, Katharina Zittlau, Boris Macek, Marisa Schmitt, Tobias Sinnberg, Katrin Bratl, Nicolas C. Nalpas
Publikováno v:
Molecular & Cellular Proteomics : MCP
Analysis of nucleotide variants is a cornerstone of cancer medicine. Although only 2% of the genomic sequence is protein coding, mutations occurring in these regions have the potential to influence protein structure or modification status and may hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d55738d47a8fb0d6432cd9bffb21f1
http://europepmc.org/articles/PMC8603206
http://europepmc.org/articles/PMC8603206
Autor:
Gustavo M. Silva, Nathan A. Snyder
Publikováno v:
The Journal of Biological Chemistry
Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability. To regulate this process, deubiquitinating enzymes (DUBs) counte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c743630c2855f90492c29a0b696db4
http://europepmc.org/articles/PMC8424594
http://europepmc.org/articles/PMC8424594
Autor:
Anouk Becker, Chih Hang Anthony Tang, Djenet Bousbaine, Matthias C. Truttmann, Corey M. Porter, Angelina M. Bilate, Chih-Chi Andrew Hu, Charlotte Wijne, Bhaskar K. Chatterjee, Hidde L. Ploegh, Nicholas McCaul
Publikováno v:
The Journal of Biological Chemistry
Fic domain-containing AMP transferases (fic AMPylases) are conserved enzymes that catalyze the covalent transfer of AMP to proteins. This posttranslational modification regulates the function of several proteins, including the ER-resident chaperone G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8454b6a2fe50baa7e5b5675a4d56b5
http://europepmc.org/articles/PMC8441161
http://europepmc.org/articles/PMC8441161
Autor:
Bénédicte, Gaborit, Roland, Govers, Alexandre, Altié, Jean Michel, Brunel, Pierre, Morange, Franck, Peiretti
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistry
International audience; The cleavage of the insulin receptor by β-secretase 1 (BACE1) in the liver increases during diabetes, which contributes to reduce insulin receptor levels and impair insulin signaling. However, the precise signaling events tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d438b123de19467c77e8e9b4739301bb
https://hal.archives-ouvertes.fr/hal-03368302
https://hal.archives-ouvertes.fr/hal-03368302
Autor:
Lewis, Rebecca, Li, Yuping D, Hoffman, Lindsey, Hashizume, Rintaro, Gravohac, Gordan, Rice, Gavin, Wadhwani, Nitin R, Jie, Chunfa, Pundy, Tatiana, Mania-Farnell, Barbara, Mayanil, Chandra S, Soares, Marcelo B, Lei, Ting, James, Charles D, Foreman, Nicolas K, Tomita, Tadanori, Xi, Guifa
Publikováno v:
Neoplasia (New York, N.Y.)
BACKGROUND: Ependymomas (EPNs) are the third most common brain tumor in children. These tumors are resistant to available chemotherapeutic treatments, therefore new effective targeted therapeutics must be identified. Increasing evidence shows epigene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b0250a9dba4bd67d2a940c6f882c20a
http://europepmc.org/articles/PMC6477190
http://europepmc.org/articles/PMC6477190
Publikováno v:
The Journal of Biological Chemistry
Biochemical studies require large quantities of proteins, which are typically obtained using bacterial overexpression. However, the folding machinery in bacteria is inadequate for expressing many mammalian proteins, which additionally undergo posttra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159eee0e43b51fb9bc443b59efa74b3d
https://doi.org/10.1101/2021.04.05.438513
https://doi.org/10.1101/2021.04.05.438513
Publikováno v:
Redox Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Redox Biology, Vol 44, Iss, Pp 102014-(2021)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Redox Biology, Vol 44, Iss, Pp 102014-(2021)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
11 p.-2 fig.-3 tab.
The cytoskeleton is a supramolecular structure consisting of interacting protein networks that support cell dynamics in essential processes such as migration and division, as well as in responses to stress. Fast cytoskeletal
The cytoskeleton is a supramolecular structure consisting of interacting protein networks that support cell dynamics in essential processes such as migration and division, as well as in responses to stress. Fast cytoskeletal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6a8d1220d7debbaa199edf8fd1e5be
https://pubmed.ncbi.nlm.nih.gov/34062408
https://pubmed.ncbi.nlm.nih.gov/34062408
Autor:
De-Chen Lin, Li-Yan Xu, Zhenchang Guo, Shanshan Tian, Feng Pan, Pu Chen, Hanyang Dong, Ji-Wei Jiao, Xiu-E Xu, Zhi-Yong Wu, Jian-Yi Wu, En-Min Li, Xue Bai, Guijin Zhai, Liu Peng, Kai Zhang, Congcong Lu, Lian-Di Liao
Publikováno v:
Molecular & Cellular Proteomics : MCP
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with poor therapeutic outcomes. However, the alterations in proteins and posttranslational modifications (PTMs) leading to the pathogenesis of ESCC remain unclear. Here, we provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3513d9451853ba46e7b4e8c1527c808c
http://europepmc.org/articles/PMC7970140
http://europepmc.org/articles/PMC7970140