Zobrazeno 1 - 10
of 37
pro vyhledávání: '"PTM, Posttranslational Modification"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 599-608 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 599-608 (2021)
Redox-altered plasticity refers to redox-dependent reversible changes in synaptic plasticity via altering functions of key proteins, such as N-methyl-d-aspartate receptor (NMDAR). Age-related cognitive disorders includes Alzheimer's disease (AD), vas
Autor:
Benjamin C. Blum, Weiwei Lin, Matthew L. Lawton, Qian Liu, Julian Kwan, Isabella Turcinovic, Ryan Hekman, Pingzhao Hu, Andrew Emili
Publikováno v:
Molecular & Cellular Proteomics : MCP
Metabolism is recognized as an important driver of cancer progression and other complex diseases, but global metabolite profiling remains a challenge. Protein expression profiling is often a poor proxy since existing pathway enrichment models provide
Autor:
Claus Garbe, Katharina Zittlau, Boris Macek, Marisa Schmitt, Tobias Sinnberg, Katrin Bratl, Nicolas C. Nalpas
Publikováno v:
Molecular & Cellular Proteomics : MCP
Analysis of nucleotide variants is a cornerstone of cancer medicine. Although only 2% of the genomic sequence is protein coding, mutations occurring in these regions have the potential to influence protein structure or modification status and may hav
Autor:
Gustavo M. Silva, Nathan A. Snyder
Publikováno v:
The Journal of Biological Chemistry
Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability. To regulate this process, deubiquitinating enzymes (DUBs) counte
Autor:
Anouk Becker, Chih Hang Anthony Tang, Djenet Bousbaine, Matthias C. Truttmann, Corey M. Porter, Angelina M. Bilate, Chih-Chi Andrew Hu, Charlotte Wijne, Bhaskar K. Chatterjee, Hidde L. Ploegh, Nicholas McCaul
Publikováno v:
The Journal of Biological Chemistry
Fic domain-containing AMP transferases (fic AMPylases) are conserved enzymes that catalyze the covalent transfer of AMP to proteins. This posttranslational modification regulates the function of several proteins, including the ER-resident chaperone G
Autor:
Bénédicte, Gaborit, Roland, Govers, Alexandre, Altié, Jean Michel, Brunel, Pierre, Morange, Franck, Peiretti
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistry
International audience; The cleavage of the insulin receptor by β-secretase 1 (BACE1) in the liver increases during diabetes, which contributes to reduce insulin receptor levels and impair insulin signaling. However, the precise signaling events tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d438b123de19467c77e8e9b4739301bb
https://hal.archives-ouvertes.fr/hal-03368302
https://hal.archives-ouvertes.fr/hal-03368302
Autor:
Lewis, Rebecca, Li, Yuping D, Hoffman, Lindsey, Hashizume, Rintaro, Gravohac, Gordan, Rice, Gavin, Wadhwani, Nitin R, Jie, Chunfa, Pundy, Tatiana, Mania-Farnell, Barbara, Mayanil, Chandra S, Soares, Marcelo B, Lei, Ting, James, Charles D, Foreman, Nicolas K, Tomita, Tadanori, Xi, Guifa
Publikováno v:
Neoplasia (New York, N.Y.)
BACKGROUND: Ependymomas (EPNs) are the third most common brain tumor in children. These tumors are resistant to available chemotherapeutic treatments, therefore new effective targeted therapeutics must be identified. Increasing evidence shows epigene
Publikováno v:
The Journal of Biological Chemistry
Biochemical studies require large quantities of proteins, which are typically obtained using bacterial overexpression. However, the folding machinery in bacteria is inadequate for expressing many mammalian proteins, which additionally undergo posttra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159eee0e43b51fb9bc443b59efa74b3d
https://doi.org/10.1101/2021.04.05.438513
https://doi.org/10.1101/2021.04.05.438513
Publikováno v:
Redox Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Redox Biology, Vol 44, Iss, Pp 102014-(2021)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Redox Biology, Vol 44, Iss, Pp 102014-(2021)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
11 p.-2 fig.-3 tab.
The cytoskeleton is a supramolecular structure consisting of interacting protein networks that support cell dynamics in essential processes such as migration and division, as well as in responses to stress. Fast cytoskeletal
The cytoskeleton is a supramolecular structure consisting of interacting protein networks that support cell dynamics in essential processes such as migration and division, as well as in responses to stress. Fast cytoskeletal
Autor:
De-Chen Lin, Li-Yan Xu, Zhenchang Guo, Shanshan Tian, Feng Pan, Pu Chen, Hanyang Dong, Ji-Wei Jiao, Xiu-E Xu, Zhi-Yong Wu, Jian-Yi Wu, En-Min Li, Xue Bai, Guijin Zhai, Liu Peng, Kai Zhang, Congcong Lu, Lian-Di Liao
Publikováno v:
Molecular & Cellular Proteomics : MCP
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with poor therapeutic outcomes. However, the alterations in proteins and posttranslational modifications (PTMs) leading to the pathogenesis of ESCC remain unclear. Here, we provide