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The mechanisms that regulate the localization and overexpression of VEGF receptor-2 are promising therapeutic targets in cancer biology

Publikováno v: Anti-Cancer Drugs. 23(4):347-354

The vascular endothelial growth factor (VEGF) family has been proposed to be the most important signaling protein family in vessel formation and maturation. VEGF receptor-2 (VEGFR-2) plays an abundant role in the most common forms of cancer. The loca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::91b71208510b86f7ec274c9f25b05de5
https://doi.org/10.1097/CAD.0b013e32835004ac

Mesenchymal Stem Cells Contribute to Tumor Cell Proliferation by Direct Cell-Cell Contact Interactions

Autor: Tiny G. J. Meeuwsen-de Boer, Eveline S. J. M. de Bont, Willem A. Kamps, Arja ter Elst, Berber D. Roorda

Publikováno v: Cancer Investigation, 28(5), 526-534. Taylor & Francis Group

Bone marrow (BM)-derived mesenchymal stem cells (MSCs) have been implicated in tumor progression, making MSCs important targets for anti-cancer strategies. In this study, we show that MSCs promote tumor growth in vivo in a lymphoma xenograft model. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d241db6ac62f8a17d2d02641f6da32
https://hdl.handle.net/11370/55c2afa3-0e43-4383-a853-0894f293f828

PTK787/ZK 222584 inhibits tumor growth promoting mesenchymal stem cells Kinase activity profiling as powerful tool in functional studies

Publikováno v: Cancer biology & therapy. 8(13):1239-1248

Bone marrow (BM)-derived mesenchymal stem cells (MSCs) have been shown to favor tumor growth, suggesting the relevance of pharmaceutical inhibition of MSCs for the treatment of malignancies. We tested the effect of PTK787/ZK 222584 (PTK) on the outgr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::97137651caa552afd478edac1b41946a
https://research.rug.nl/en/publications/1ef9c624-d9bb-4243-acec-8f17492e0f1e

Oral tyrosine kinase inhibitors targeting VEGF-receptors in patients with metastatic colorectal cancer

Autor: Qvortrup, C., Pfeiffer, P.

Publikováno v: Qvortrup, C & Pfeiffer, P 2015, ' Oral tyrosine kinase inhibitors targeting VEGF-receptors in patients with metastatic colorectal cancer ', Translational Gastrointestinal Cancer, vol. 4, no. 2, pp. 108-111 . https://doi.org/10.3978/j.issn.2224-4778.2014.08.12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::da127a2f164e91305b974170f60f90dc
https://portal.findresearcher.sdu.dk/da/publications/93c5bda7-c1ca-410f-b519-f327d22230f6