Zobrazeno 1 - 3
of 3
pro vyhledávání: '"PTEN fosfohidrolasa"'
Autor:
Elez, Elena, Pericay, Carles, Valladares-Ayerbes, Manuel, Bando, Inmaculada, Safont, Maria Jose, Gallego, Javier, Grávalos, Cristina, Arrivi, Antonio, Carrato, Alfredo, Conde, Verónica, Ortiz, Maria José, López, Carlos, Alonso, Beatriz, Ruiz de Mena, Inmaculada, Díaz-Rubio, Eduardo, Tabernero, Josep, Aranda, Enrique, Universitat Autònoma de Barcelona
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
British Journal of Cancer
Universitat Autònoma de Barcelona
British Journal of Cancer
BACKGROUND: Targeted agents are standard treatment for RAS wild-type metastatic colorectal cancer in the first- and second-line settings. This phase 2 study determined the benefit of targeting the epidermal growth factor receptor (EGFR) with panitumu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068001b4d36d161525fefa9dd7e823b6
https://hdl.handle.net/10668/14342
https://hdl.handle.net/10668/14342
Autor:
Alberto Orfao, José M. Medina, Arantxa Tabernero, Myriam Jaraíz-Rodríguez, Álvaro Otero, Ma Dolores Tabernero, María González-Tablas
Publikováno v:
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
GREDOS: Repositorio Institucional de la Universidad de Salamanca
Universidad de Salamanca (USAL)
Stem Cell Reports, Vol 9, Iss 2, Pp 451-463 (2017)
Digital.CSIC. Repositorio Institucional del CSIC
Stem Cell Reports
instname
GREDOS: Repositorio Institucional de la Universidad de Salamanca
Universidad de Salamanca (USAL)
Stem Cell Reports, Vol 9, Iss 2, Pp 451-463 (2017)
Digital.CSIC. Repositorio Institucional del CSIC
Stem Cell Reports
Summary Connexin43 (CX43), a protein that forms gap junction channels and hemichannels in astrocytes, is downregulated in high-grade gliomas. Its relevance for glioma therapy has been thoroughly explored; however, its positive effects on proliferatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c2b041a5d90f07c043516feb7b9d51
http://hdl.handle.net/10366/140751
http://hdl.handle.net/10366/140751
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation
Autor:
Rayman Choo-Wing, John M. Asara, Dimitrios Anastasiou, Mark J. Arends, Gelareh Zadeh, Adamo Valle, Nikos Koundouros, Yuxiang Zheng, George Poulogiannis, Amit Gupta, Lewis C. Cantley, Yu-Hsin Chiu, Maria Dimitriadi, Sara Anjomani-Virmouni, Sameer Agnihotri
Publikováno v:
Gupta, A, Anjomani-Virmouni, S, Koundouros, N, Dimitriadi, M, Choo-Wing, R, Valle, A, Zheng, Y, Chiu, Y-H, Agnihotri, S, Zadeh, G, Wagner, M, M. Asara, J, Anastasiou, D, Arends, M J, Cantley, L C & Poulogiannis, G 2017, ' PARK2 depletion connects energy and oxidative stress to PI3K/Akt activation via PTEN S-nitrosylation ', Molecular Cell, vol. 65, no. 6, pp. 999-1013.e7 . https://doi.org/10.1016/j.molcel.2017.02.019
PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely unknown. Here we show that PARK2 is altered in over a third of all human cancers, and its deple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8382cb9e16caada1493c79977d1b5ea
https://doi.org/10.1016/j.molcel.2017.02.019
https://doi.org/10.1016/j.molcel.2017.02.019
