Crosstalk between the RNA Methylation and Histone-Binding Activities of MePCE Regulates P-TEFb Activation on Chromatin

Autor: Samantha B. Shelton, Nakul M. Shah, Nathan S. Abell, Sravan K. Devanathan, Marvin Mercado, Blerta Xhemalçe

Publikováno v: Cell Reports, Vol 22, Iss 6, Pp 1374-1383 (2018)

Summary: RNAP II switching from the paused to the productive transcription elongation state is a pivotal regulatory step that requires specific phosphorylations catalyzed by the P-TEFb kinase. Nucleosolic P-TEFb activity is inhibited by its interacti

Externí odkaz: https://doaj.org/article/bd2a55bdc6824da2a0698ba7630c590d

Heat shock induces premature transcript termination and reconfigures the human transcriptome

Autor: Simona Cugusi, Richard Mitter, Gavin P. Kelly, Jane Walker, Zhong Han, Paola Pisano, Michael Wierer, Aengus Stewart, Jesper Q. Svejstrup

Publikováno v: Cugusi, S, Mitter, R, Kelly, G P, Walker, J, Han, Z, Pisano, P, Wierer, M, Stewart, A & Svejstrup, J Q 2022, ' Heat shock induces premature transcript termination and reconfigures the human transcriptome ', Molecular Cell, vol. 82, no. 8, pp. 1573-1588.e10 . https://doi.org/10.1016/j.molcel.2022.01.007

The heat shock (HS) response involves rapid induction of HS genes, whereas transcriptional repression is established more slowly at most other genes. Previous data suggested that such repression results from inhibition of RNA polymerase II (RNAPII) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3791b8e421bee82b22d02a1732ed817e
https://curis.ku.dk/portal/da/publications/heat-shock-induces-premature-transcript-termination-and-reconfigures-the-human-transcriptome(ef04157d-7665-46bf-a846-5be197ecd524).html

Tools for molecular dynamics applied to transcriptional regulation study

Autor: Fournier, Marie

Publikováno v: Physique Médicale [physics.med-ph]. Université de Lille, 2021. Français. ⟨NNT : 2021LILUR004⟩

Every biological organism is a complex system that responds to the constraints of a program linked to its perpetuation and its environment. The regulation of transcription is one of the fundamental adaptation mechanisms of living organisms. The dynam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8dced192bd45f5cf32730c7fd3849f97
https://theses.hal.science/tel-03510376/file/These_FOURNIER_Marie.pdf

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Tip110 Expression Facilitates the Release of HEXIM1 and pTEFb from the 7SK Ribonucleoprotein Complex Involving Regulation of the Intracellular Redox Level

Autor: Ying, Liu, Lu, Li, Khalid, Timani, Carl, White, Johnny J, He

Publikováno v: Aging and Disease

HIV-1 Tat-interacting protein of 110 kDa (Tip110; p110nrb/SART3) has been identified to be important for HIV gene transcription and several host gene expression. In this study, we showed that Tip110 was present in the 7SK snRNP through direct binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b317e6ae2b01f36adbd874defa94fe
https://doi.org/10.14336/ad.2021.0528