Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

Autor: Wenfu Tan, Huaqian Ding, Xiaohua Liu, Chunyong Ding, Juan Wang, Yalei Li, Ao Zhang, Yu Zhang, Hongchun Liu, Wenjing Huang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 488-504 (2021)
Acta Pharmaceutica Sinica. B

Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301cde2b3eb755a22e93dd5c8eb925b1
https://doi.org/10.1016/j.apsb.2020.07.007

Infantile-onset palmo-plantar basal cell carcinomas and pits in Gorlin syndrome

Autor: Louis-Philippe Gagnon, Claire Coulombe, Marie-Claude Dionne, Valerie Larouche

Publikováno v: JAAD Case Reports

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4290e314f215f6b89024d7a77e7b6c32
https://doi.org/10.1016/j.jdcr.2018.06.017

Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells

Autor: Cinzia Giordano, Annette Bakker, Marco Rossi, Rossana Ritelli, Mario D'Andrea, Licia Montagna, Letizia Magnoni, Patrizia Tunici, Silvia Valensin, Margherita Gaviraghi, Aldo Scarpa

Publikováno v: Bioscience Reports

Pancreatic cancer stem-like cells are described by membrane expression of CD24, CD44 and ESA (epithelial-specific antigen) and their capacity to grow as spheres in a serum-free medium containing well-defined growth factors. The capacity of a panel of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4181059a6e46ecbce5c52562d00f1fef
https://doi.org/10.1042/bsr20100018

A case of Gorlin syndrome like phenotype with multiple infundibulocystic basal cell carcinomas in a moniliform blepharosis arrangement.

Autor: Petrosian D; Department of Family Medicine, St. John's Episcopal Hospital, Far Rockaway, New York., Reiter P; Department of Dermatology, St. John's Episcopal Hospital, Far Rockaway, New York., Rozenberg SS; Department of Dermatology, St. John's Episcopal Hospital, Far Rockaway, New York., Petrosian S; Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

Publikováno v: JAAD case reports [JAAD Case Rep] 2023 Feb 11; Vol. 34, pp. 27-31. Date of Electronic Publication: 2023 Feb 11 (Print Publication: 2023).

Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma.

Autor: Liu X; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhang Y; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Li Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China., Wang J; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Ding H; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Huang W; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Ding C; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Liu H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China., Tan W; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Zhang A; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Esophageal Cancer Prevention and Treatment, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, China.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Feb; Vol. 11 (2), pp. 488-504. Date of Electronic Publication: 2020 Jul 21.