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Clinical implications of shared genetics and pathogenesis in autoimmune diseases

Autor: Cisca Wijmenga, Alexandra Zhernakova, Sebo Withoff

Publikováno v: Nature Reviews Endocrinology

Many endocrine diseases, including type 1 diabetes mellitus, Graves disease, Addison disease and Hashimoto disease, originate as an autoimmune reaction that affects disease-specific target organs. These autoimmune diseases are characterized by the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2435ae29d1fd77c237e7087ff80bf2e
https://doi.org/10.1038/nrendo.2013.161

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

Autor: Tom H. Karlsen, Mauro D'Amato, Valerie Collij, Michael Weichenthal, Adrian Cortes, Konstantinos N. Lazaridis, Trine Folseraas, Stephan Weidinger, Jonathan Barker, Tune H. Pers, Richard C. Trembath, Andre Franke, Andres Metspalu, David Ellinghaus, Tõnu Esko, Ulrich Mrowietz, Søren Brunak, Matthias Hübenthal, James T. Elder, Dermot P.B. McGovern, Matthew A. Brown, Jonas Halfvarson, Jeffrey C. Barrett, Lude Franke, Ole A. Andreassen, Yunpeng Wang, Harm-Jan Westra, Anders Boeck Jensen, Anders M. Dale, Yu Rang Park, Brian D. Juran, Andreas J. Forstner, Jörn Bethune, Jennie G. Pouget, Stephan Schreiber, Wolfgang Lieb, Luke Jostins, Miles Parkes, Eva Ellinghaus, Sarah L. Spain, Franziska Degenhardt, Buhm Han, Rinse K. Weersma, Andrea Hofmann, Soumya Raychaudhuri

Publikováno v: Nature Genetics
Nature genetics
Nature Genetics, 48(5), 510-518. Nature Publishing Group
Ellinghaus, D, Jostins, L, Spain, S L, Cortes, A, Bethune, J, Han, B, Park, Y R, Raychaudhuri, S, Pouget, J G, Hübenthal, M, Folseraas, T, Wang, Y, Esko, T, Metspalu, A, Westra, H J, Franke, L, Pers, T H, Weersma, R K, Collij, V, D'Amato, M, Halfvarson, J, Jensen, A B, Lieb, W, Degenhardt, F, Forstner, A J, Hofmann, A, Schreiber, S, Mrowietz, U, Juran, B D, Lazaridis, K N, Brunak, SØ, Dale, A M, Trembath, R C, Weidinger, S, Weichenthal, M, Ellinghaus, E, Elder, J T, Barker, J N W N, Andreassen, O A, McGovern, D P, Karlsen, T H, Barrett, J C, Parkes, M, Brown, M A & Franke, A 2016, ' Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci ', Nature Genetics, vol. 48, no. 5, pp. 510-518 . https://doi.org/10.1038/ng.3528
Ellinghaus, D; Jostins, L; Spain, SL; Cortes, A; Bethune, J; Han, B; et al.(2016). Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics, 48(5), 510-518. doi: 10.1038/ng.3528. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/1k10m53k

© 2016 Nature America, Inc. We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab7cb9204cbb598349b89b8132a199f

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