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Characterization and expression of the microtubule associated protein tau gene isoforms and their impact on clinical outcomes in glioma patients

Autor: Hidalgo, Axel M., Singh, Vipin, Mangadu, Thenral, Guha, Deblina, Ramos, Enrique I., Das, Chandrima, Gadad, Shrikanth S.

Publikováno v: In Computational and Structural Biotechnology Reports December 2024 1

Accumulation of microtubule-associated protein tau promotes hepatocellular carcinogenesis through inhibiting autophagosome-lysosome fusion.

Autor: Liu X; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Hao Z; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China., He H; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China., Wang X; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China., Wang W; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China., Shu X; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Sun B; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China.; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Hu Z; Department of Pathology, Renmin Hospital of Huangpi District of Jianghan University, Wuhan, 430399, China., Hu S; Liver Transplant Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China., Hou X; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China., Xiao Y; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Zhou H; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Liu Y; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China. yuchen.liu@jhun.edu.cn.; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. yuchen.liu@jhun.edu.cn.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. yuchen.liu@jhun.edu.cn., Wang J; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. wangjz@mail.hust.edu.cn.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. wangjz@mail.hust.edu.cn., Fu Z; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China. lilyfzq@163.com.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China. lilyfzq@163.com.

Publikováno v: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Dec 24. Date of Electronic Publication: 2024 Dec 24.

Changes in Oxidised Phospholipids in Response to Oxidative Stress in Microtubule-Associated Protein Tau (MAPT) Mutant Dopamine Neurons

Autor: Xanthe Bradford, Hugo J. R. Fernandes, Stuart G. Snowden

Publikováno v: Antioxidants, Vol 13, Iss 5, p 508 (2024)

Microtubule-associated protein Tau (MAPT) is strongly associated with the development of neurodegenerative diseases. In addition to driving the formation of neurofibrillary tangles (NFT), mutations in the MAPT gene can also cause oxidative stress thr

Externí odkaz: https://doaj.org/article/7b5d9316109047299c836f5e111e7b20

Molecular Deformation Is a Key Factor in Screening Aggregation Inhibitor for Intrinsically Disordered Protein Tau

Autor: Keke Chai, Jian Yang, Ying Tu, Junjie Wu, Kang Fang, Shuo Shi, Tianming Yao

Publikováno v: ACS Central Science, Vol 10, Iss 3, Pp 717-728 (2024)

Externí odkaz: https://doaj.org/article/1ff570bda3904ff290a1e2d63a0eb9cb