Zobrazeno 1 - 10
of 1 077
pro vyhledávání: '"PROTEIN app"'
Autor:
María Pagnon de la Vega, Stina Syvänen, Vilmantas Giedraitis, Monique Hooley, Evangelos Konstantinidis, Silvio R. Meier, Johanna Rokka, Jonas Eriksson, Ximena Aguilar, Tara L. Spires-Jones, Lars Lannfelt, Lars N. G. Nilsson, Anna Erlandsson, Greta Hultqvist, Martin Ingelsson, Dag Sehlin
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Deposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer’s disease (AD). Different amyloid precursor protein (APP) mutations cause early-onset AD by altering the production or aggregation properties of Aβ. We recentl
Externí odkaz:
https://doaj.org/article/e1e6c9096c0f4e3e9f714a2564198215
Autor:
Tsu-Kung Lin, Chi-Ren Huang, Kai-Jung Lin, Yi-Heng Hsieh, Shang-Der Chen, Yi-Chun Lin, A-Ching Chao, Ding-I Yang
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1378 (2024)
The major pathological characteristics of Alzheimer’s disease (AD) include senile plaques and neurofibrillary tangles (NFTs), which are mainly composed of aggregated amyloid-beta (Aβ) peptide and hyperphosphorylated tau protein, respectively. The
Externí odkaz:
https://doaj.org/article/3ec10bfd3daa46cd8efc27baa4f42ee8
Autor:
Mojgan Rastegar
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Externí odkaz:
https://doaj.org/article/ed0d7cef255d4b3d93135cab1c0e5bcf
Autor:
James A. Langeland, Lillian Baumann, Eva M. DeYoung, Raphaela Angelina Varella, Nkatha Mwenda, Alejandro Aguirre, D. Blaine Moore
Publikováno v:
Biology, Vol 13, Iss 5, p 320 (2024)
Alzheimer’s disease is characterized, in part, by the accumulation of β-amyloid (Aβ) in the brain. Aβ is produced via the proteolysis of APP by BACE1 and γ-secretase. Since BACE1 is the rate-limiting enzyme in the production of Aβ, and a targe
Externí odkaz:
https://doaj.org/article/911b24f1a258409588d90d17cbe67305
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106294- (2023)
Interictal spikes (IIS) are a common type of abnormal electrical activity in Alzheimer's disease (AD) and preclinical models. The brain regions where IIS are largest are not known but are important because such data would suggest sites that contribut
Externí odkaz:
https://doaj.org/article/1fa6bd3e39044a8fa130e3ef345f0d6a
Akademický článek
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Autor:
Khue Vu Nguyen
Publikováno v:
AIMS Neuroscience, Vol 9, Iss 2, Pp 175-215 (2022)
A heterozygous Arg393His point mutation at the reactive site of antithrombin (AT) gene causing thrombosis in a Vietnamese patient is reported and named as Arg393His in AT-Hanoi. The present variant is characterized by a severe reduction of functional
Externí odkaz:
https://doaj.org/article/1f5c51639c4a4885a406cbcd8a40b05c
Autor:
Aaron Johnstone, William Mobley
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/d46b31d5fde84a34b6acfc85aef61452
Autor:
Viktoriya Indzhova, Michał Czopowicz, Scott Kilpatrick, Rodrigo Gutierrez-Quintana, Josep Brocal
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionThis retrospective multicentric study aims to evaluate the ability of CRP concentration to differentiate between dogs diagnosed with IMPA and SRMA. C-reactive protein (CRP) is a marker of inflammation widely used in two of the most common
Externí odkaz:
https://doaj.org/article/f0c990751dbb4207b608adb8dd59dfc7
Autor:
Khue Vu Nguyen
Publikováno v:
AIMS Neuroscience, Vol 8, Iss 4, Pp 548-557 (2021)
Lesch-Nyhan disease (LND) is a rare X-linked inherited neurogenetic disorders of purine metabolic in which the cytoplasmic enzyme, hypoxanthine-guanine phosphoribosyltransferase (HGprt) is defective. Despite having been characterized over 60 years ag
Externí odkaz:
https://doaj.org/article/87a45eae98444dcf8a8626b01e50e7e2