Zobrazeno 1 - 10
of 2 878
pro vyhledávání: '"PROTEASOMAL DEGRADATION"'
Autor:
Yu-Ying Liu, Yu-Ying Zhang, Ling-Yu Ran, Bo Huang, Jun-Wu Ren, Qiang Ma, Xiao-Juan Pan, Fei-Fei Yang, Ce Liang, Xiao-Lin Wang, Shi-Min Wang, Ai Ran, Hao Ning, Yan Jiang, Chang-Hong Qin, Bin Xiao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Gastric cancer (GC) ranks fifth in global cancer incidence and third in mortality rate among all cancer types. Circular RNAs (circRNAs) have been extensively demonstrated to regulate multiple malignant biological behaviors in GC.
Externí odkaz:
https://doaj.org/article/b5c71a395f294b6da646379ed3dc5f7d
Publikováno v:
Cell Structure and Function, Vol 49, Iss 1, Pp 11-20 (2024)
The ribosome is a molecular machine essential for protein synthesis, which is composed of approximately 80 different ribosomal proteins (Rps). Studies in yeast and cell culture systems have revealed that the intracellular level of Rps is finely regul
Externí odkaz:
https://doaj.org/article/ea73a41e7a5040609ba4c177a90465cc
Differential stability of Gcn4p controls its cell-specific activity in differentiated yeast colonies
Autor:
Libuše Váchová, Vítězslav Plocek, Jana Maršíková, Stanislava Rešetárová, Ladislava Hatáková, Zdena Palková
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTGcn4p belongs to conserved AP-1 transcription factors involved in many cellular processes, including cell proliferation, stress response, and nutrient availability in yeast and mammals. AP-1 activities are regulated at different levels, such
Externí odkaz:
https://doaj.org/article/d74ea830131f48d59b2135d3beb053a0
Autor:
Li Sun, Hongbo Gao, Han Wang, Jingwei Zhou, Xiuru Ji, Yuxin Jiao, Xiaojia Qin, Dalong Ni, Xiangpeng Zheng
Publikováno v:
Advanced Science, Vol 11, Iss 12, Pp n/a-n/a (2024)
Abstract Activating cGAS‐STING pathway has great potential to achieve effective antitumor immunotherapy. However, mutant p53 (mutp53), a commonly observed genetic alteration in over 50% of human cancer, will impede the therapeutic performance of th
Externí odkaz:
https://doaj.org/article/3a02d2920bb6463eaf82490fbc73aa97
Autor:
Rebecca R. Florke Gee, Andrew D. Huber, Jing Wu, Richa Bajpai, Allister J. Loughran, Shondra M. Pruett-Miller, Taosheng Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 11, Pp 4523-4534 (2023)
Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [e.g., cytochrome P450 3A4 (CYP3A4)] and transporters. Although the regulation of PXR target genes is well-characterized, le
Externí odkaz:
https://doaj.org/article/5971bd48286446cb86209bac424bd79b
Publikováno v:
Journal of Dental Sciences, Vol 18, Iss 4, Pp 1588-1597 (2023)
Background/purpose: Proliferation-associated protein 2G4 (PA2G4) has alternative transcriptional and translational initiation. One dominant transcript ENST00000303305 could be translated into two protein isoforms (PA2G4-P42 and PA2G4-P48). In this st
Externí odkaz:
https://doaj.org/article/19e1934cf5e1419780ab3f9dc61d85fe
Publikováno v:
Cancer Medicine, Vol 13, Iss 4, Pp n/a-n/a (2024)
Abstract Background Tumor metastasis and recurrence are major causes of mortality in patients with hepatocellular carcinoma (HCC) that is still lack of effective therapeutic targets and drugs. Previous reports implied that ras homolog family member C
Externí odkaz:
https://doaj.org/article/b4d47d72596a49b5bda156c0e0bd0312
Autor:
Linran Zhang, Pengfei Hao, Xiang Chen, Shuai Lv, Wenying Gao, Chang Li, Zhaolong Li, Wenyan Zhang
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT The accessory protein ORF6 of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key interferon (IFN) antagonist that strongly suppresses the production of primary IFN as well as the expression of IFN-stimulated genes. How
Externí odkaz:
https://doaj.org/article/335c6f1603844ab391edf0e169b50722
Publikováno v:
Viruses, Vol 16, Iss 5, p 728 (2024)
APOBEC3G (A3G) restricts HIV-1 replication primarily by reducing viral cDNA and inducing G-to-A hypermutations in viral cDNA. HIV-1 encodes virion infectivity factor (Vif) to counteract A3G primarily by excluding A3G viral encapsidation. Even though
Externí odkaz:
https://doaj.org/article/7f03734246de412db851961cf38e2610
Publikováno v:
Poultry Science, Vol 102, Iss 11, Pp 103026- (2023)
ABSTRACT: More and more studies have demonstrated that proteasomal degradation occurs in the development of various diseases, including ventricular remodeling, which is a cardiac pathological change and seriously makes patient outcomes worse. Our pre
Externí odkaz:
https://doaj.org/article/be90ba5b804f4f4085208dab642d2157