Zobrazeno 1 - 10
of 2 743
pro vyhledávání: '"PROTAC"'
Autor:
Yawen Dong, Tingting Ma, Ting Xu, Zhangyan Feng, Yonggui Li, Lingling Song, Xiaojun Yao, Charles R. Ashby, Jr, Ge-Fei Hao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4266-4295 (2024)
Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking development in drug discovery, leveraging the ubiquitin‒proteasome system to specifically degrade proteins responsible for the disease. PROTAC is characterized by its uni
Externí odkaz:
https://doaj.org/article/8aa4210351db425b9ddf81c7e5082d5f
Autor:
Hao Yan, Ruge Zang, Tiantian Cui, Yiming Liu, Biao Zhang, Lingpin Zhao, Hongyu Li, Juannian Zhou, Haiyang Wang, Quan Zeng, Lei Xu, Yuqi Zhou, Xuetao Pei, Jiafei Xi, Wen Yue
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), can undergo erythroid differentiation, offering a potentially invaluable resource for generating large
Externí odkaz:
https://doaj.org/article/8d847198eb7849ca8a7b9af25734b196
Autor:
Vikram Tejwani, Thomas Carroll, Thomas Macartney, Susanne Bandau, Constance Alabert, Giulia Saredi, Rachel Toth, John Rouse
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a pr
Externí odkaz:
https://doaj.org/article/78e1855099f841b080867cac0d25d57d
Autor:
Shuqiang Chen, Kaijian Bi, Huixin Liang, Zhe Wu, Min Huang, Xi Chen, Guoqiang Dong, Chunquan Sheng
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 219-230 (2024)
Introduction: Natural products (NPs) play a crucial role in the development of therapeutic drugs. However, it is still highly challenging to identify the targets of NPs. Besides, NPs usually exert their pharmacological activities via acting on multip
Externí odkaz:
https://doaj.org/article/34c6a20193714688bf70038f67842f9d
Autor:
Anita G. Kansy, Ramy Ashry, Al‐Hassan M. Mustafa, Abdallah M. Alfayomy, Markus P. Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver H. Krämer
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1958-1965 (2024)
Mammalian cells replicate ~ 3 × 109 base pairs per cell cycle. One of the key molecules that slows down the cell cycle and prevents excessive DNA damage upon DNA replication stress is the checkpoint kinase ataxia‐telangiectasia‐and‐RAD3‐rela
Externí odkaz:
https://doaj.org/article/3c603aa7f4ed49c783038eaa1696cb4c
Autor:
Di Wu, Hongli Yin, Chun Yang, Zimu Zhang, Fang Fang, Jianwei Wang, Xiaolu Li, Yi Xie, Xiaohan Hu, Ran Zhuo, Yanling Chen, Juanjuan Yu, Tiandan Li, Gen Li, Jian Pan
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone. Recently, Super-Enhancers(SEs)have been repo
Externí odkaz:
https://doaj.org/article/062afa89ce6c401580b5461a311d4c4c
Autor:
M. A. Zakharova, M. V. Chudinov
Publikováno v:
Тонкие химические технологии, Vol 19, Iss 3, Pp 214-231 (2024)
Objectives. To describe the pharmaceutical technology of controlled degradation of protein molecules (PROTAC®, Proteolysis Targeting Chimera), approaches to the design of the PROTAC® molecule, methods of ligand and linker selection and synthesis, a
Externí odkaz:
https://doaj.org/article/ada0adb00df44d4e8dbe708ae2f25183
Autor:
Tatyana A. Grigoreva, Daria S. Novikova, Gerry Melino, Nick A. Barlev, Vyacheslav G. Tribulovich
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Ubiquitinylation of protein substrates results in various but distinct biological consequences, among which ubiquitin-mediated degradation is most well studied for its therapeutic application. Accordingly, artificially targeted ubiquitin-dep
Externí odkaz:
https://doaj.org/article/8b5ebc11717b499a8658c50703329cb5
Autor:
Wanyi Zou, Mengna Li, Shili Wan, Jingkun Ma, Linan Lian, Guanghao Luo, Yubo Zhou, Jia Li, Bing Zhou
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Protein arginine methyltransferase 3 (PRMT3) plays an important role in gene regulation and a variety of cellular functions, thus, being a long sought‐after therapeutic target for human cancers. Although a few PRMT3 inhibitors are develope
Externí odkaz:
https://doaj.org/article/43cce0493dd74279a4961bfa1c25e2ab
Autor:
Soohyun Lee, Hwa‐Ryeon Kim, Yaejin Woo, Jiyoung Kim, Han Wool Kim, Ji Youn Park, Beomseon Suh, Yuri Choi, Jungmin Ahn, Je Ho Ryu, Jae‐Seok Roe, Jaewhan Song, Song Hee Lee
Publikováno v:
Advanced Science, Vol 11, Iss 33, Pp n/a-n/a (2024)
Abstract The androgen receptor (AR) is an attractive target for treating prostate cancer, considering its role in the development and progression of localized and metastatic prostate cancer. The high global mortality burden of prostate cancer, despit
Externí odkaz:
https://doaj.org/article/ea8b9935704f4b0aa6c3e1d10cdfe09a