Zobrazeno 1 - 10
of 4 460
pro vyhledávání: '"PRECISION ONCOLOGY"'
Autor:
Johannes Weller, Anna‐Laura Potthoff, Thomas Zeyen, Christina Schaub, Cathrina Duffy, Matthias Schneider, Ulrich Herrlinger
Publikováno v:
Molecular Oncology, Vol 18, Iss 12, Pp 2927-2950 (2024)
The concept of precision oncology, the application of targeted drugs based on comprehensive molecular profiling, has revolutionized treatment strategies in oncology. This review summarizes the current status of precision oncology in glioblastoma (GBM
Externí odkaz:
https://doaj.org/article/e9a4c9ccc168445b969bf1b09603be97
Autor:
Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Adam Dobias, Joan Planas-Iglesias, Stanislav Mazurenko, Ihor Arefiev, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Jiri Damborsky, Ondrej Slaby, David Bednar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 24, Iss , Pp 734-738 (2024)
Next-generation sequencing technology has created many new opportunities for clinical diagnostics, but it faces the challenge of functional annotation of identified mutations. Various algorithms have been developed to predict the impact of missense v
Externí odkaz:
https://doaj.org/article/3d4ec3367bee4e13870e203cd22157b5
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2049-2056 (2024)
Multi-omics technologies, encompassing genomics, proteomics, and transcriptomics, provide profound insights into cancer biology. A fundamental computational approach for analyzing multi-omics data is differential analysis, which identifies molecular
Externí odkaz:
https://doaj.org/article/647efc60b8b44e57b892665d37e7c503
Autor:
Lucas Frederik van Schaik, Ellen Gurumay Engelhardt, Wim Herbert van Harten, Valesca Pavlawna Retèl
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Comprehensive genomic profiling (CGP) can identify targets beyond standard of care, potentially revolutionizing personalized cancer management. However, conducting well designed studies in this rapidly evolving field is complex an
Externí odkaz:
https://doaj.org/article/dfa775076b254ef5919331a8af7dd92e
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract The WNT6 ligand is a well-known activator of the WNT signaling pathway, considered a vital player in several important physiologic processes during embryonic development and maintaining homeostasis throughout life, regulating the proliferati
Externí odkaz:
https://doaj.org/article/773c252a0f1545db8f2abc416cc65e21
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 4, Pp 272-282 (2024)
An increasing number of newer targeted oncologic therapies approved for clinical use can cause drug-related pneumonitis. Drug-related pneumonitis can be difficult to diagnose and requires a high index of suspicion. This review serves as an update to
Externí odkaz:
https://doaj.org/article/675860ebbb4a4d6e852f7eea397ff0ce
Autor:
Sunhwa Baek, Fabian Dominik Mairinger, Sabrina Borchert, Yue Zhao, Dominik Ratiu, Peter Konrad Mallmann, Henryk Pilch, Ka-Won Noh
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 12075-12087 (2024)
Cervical cancer remains a leading cause of cancer-related deaths in women worldwide, with limited treatment options for advanced stages and therapy-resistant cases. Despite advances in treatment, the variability in the patient response to standard th
Externí odkaz:
https://doaj.org/article/1ec3bc22fca446ea9afa36a26b91ded1
Autor:
Yoshiko Mori, Okihide Suzuki, Noriko Tanabe, Aoi Sugino, Takehiro Shiraishi, Norimichi Chiyonobu, Kenichi Chikatani, Noriyasu Chika, Satoshi Hatano, Takatoshi Matsuyama, Keiichiro Ishibashi, Hideyuki Ishida
Publikováno v:
Journal of the Anus, Rectum and Colon, Vol 8, Iss 4, Pp 289-297 (2024)
Objectives: Although some studies have evaluated the effectiveness of comprehensive genomic profiling (CGP) in solid tumors, the effectiveness of CGP in metastatic colorectal cancer (mCRC) has not been evaluated using detailed real-world long-outcome
Externí odkaz:
https://doaj.org/article/c07ff7079e574fd788b4a0358c9bde11
Autor:
Rabab Fatima
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 1229-1231 (2024)
Externí odkaz:
https://doaj.org/article/22f67a388c28496598d101a491e2c4c6
Autor:
Ünal Metin Tokat, Ashkan Adibi, Esranur Aydın, Eylül Özgü, Şevval Nur Bilgiç, Onur Tutar, Merve Özbek Doğançay, İrem Demiray, Mutlu Demiray
Publikováno v:
Current Oncology, Vol 31, Iss 10, Pp 5838-5849 (2024)
There is currently no effective treatment strategy for recurrent/metastatic adenoid cystic carcinoma (R/M ACC). Furthermore, recent single-agent and combination immunotherapy trials have failed in unselected ACC cohorts, unlike non-ACC salivary gland
Externí odkaz:
https://doaj.org/article/7094e808ef284ab8b902545349bfdba9