Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis

Autor: Matthias C, Jahnke V, Pw, Jones, Pr, Hoban, Je, Alldersea, Sf, Worrall, Anthony Fryer, Rc, Strange

Publikováno v: Europe PubMed Central

GST, CYP, and CCND1 genotypes have been associated with outcome in several cancers. Accordingly, we have examined, in patients with one squamous cell carcinoma (SCC) of the head and neck, associations between GSTM1, GSTT1, GSTM3, GSTP1, CYP2D6, CYP1A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1a41d4c80e306ff3dd100464c4187704
http://europepmc.org/abstract/med/10498401

Association of glutathione S-transferase GSTM1 and GSTT1 null genotypes with clinical outcome in epithelial ovarian cancer

Autor: Re, Howells, Cw, Redman, Kk, Dhar, Sarhanis P, Musgrove C, Pw, Jones, Alldersea J, Anthony Fryer, Pr, Hoban, Rc, Strange

Publikováno v: Europe PubMed Central

Epithelial ovarian cancer is generally associated with a poor outcome, although the mechanisms that determine survival and progression-free interval (PFI) are unclear. Data from ovarian tumors showing associations between (a) null genotypes at the gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3c6529d520ac11bb6ef8906e70e2bc7b
http://europepmc.org/abstract/med/9796976

RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis

Autor: Monica A. Spiteri, Elizabeth Cottrell, PR Hoban, Keira L. Watts

Publikováno v: Respiratory Research
Respiratory Research, Vol 7, Iss 1, p 88 (2006)

Background Idiopathic Pulmonary Fibrosis (IPF) is a debilitating disease characterized by exaggerated extracellular matrix deposition and aggressive lung structural remodeling. Disease pathogenesis is driven by fibroblastic foci formation, consequent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d1969abd9bfe6a8940c376553cadaf

Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis.

Autor: Mamutse G; Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK., Woolmore J, Pye E, Partridge J, Boggild M, Young C, Fryer A, Hoban PR, Rukin N, Alldersea J, Strange RC, Hawkins CP

Publikováno v: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2008 Nov; Vol. 14 (9), pp. 1280-3. Date of Electronic Publication: 2008 Jul 24.

Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene.

Autor: Rukin NJ; Human Disease and Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire ST4 7PX, United Kingdom., Luscombe C, Moon S, Bodiwala D, Liu S, Saxby MF, Fryer AA, Alldersea J, Hoban PR, Strange RC

Publikováno v: Cancer letters [Cancer Lett] 2007 Mar 18; Vol. 247 (2), pp. 328-35. Date of Electronic Publication: 2006 Jul 03.