Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown

Autor: Sandra Noske, Michael Karimov, Achim Aigner, Alexander Ewe

Publikováno v: Nanomaterials, Vol 10, Iss 9, p 1809 (2020)

The delivery of small interfering RNAs (siRNA) is an efficient method for gene silencing through the induction of RNA interference (RNAi). It critically relies, however, on efficient vehicles for siRNA formulation, for transfection in vitro as well a

Externí odkaz: https://doaj.org/article/72bf15517e7b4e0486dce299967652c9

Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown.

Autor: Noske S; Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Leipzig University, Faculty of Medicine, 04107 Leipzig, Germany., Karimov M; Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Leipzig University, Faculty of Medicine, 04107 Leipzig, Germany., Aigner A; Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Leipzig University, Faculty of Medicine, 04107 Leipzig, Germany., Ewe A; Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Leipzig University, Faculty of Medicine, 04107 Leipzig, Germany.

Publikováno v: Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2020 Sep 10; Vol. 10 (9). Date of Electronic Publication: 2020 Sep 10.