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Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.

Autor: Saito K; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Sekiya M; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: msekiya@md.tsukuba.ac.jp., Kainoh K; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Yoshino R; Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan., Hayashi A; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Han SI; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Araki M; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Ohno H; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Takeuchi Y; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Tsuyuzaki T; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Yamazaki D; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Wanpei C; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Hada L; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Watanabe S; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Paramita Adi Putri PI; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Murayama Y; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Sugano Y; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Osaki Y; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Iwasaki H; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Yahagi N; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Suzuki H; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Miyamoto T; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Matsuzaka T; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan., Shimano H; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104890. Date of Electronic Publication: 2023 Jun 05.

Osteocytes contribute via nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism.

Autor: Chougule A; Department of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States., Baroi S; Department of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States., Czernik PJ; Department of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States., Crowe E; Department of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States., Chang MR; Department of Molecular Medicine, UF Scripps Biomedical Research, University of Florida, Jupiter, FL, United States., Griffin PR; Department of Molecular Medicine, UF Scripps Biomedical Research, University of Florida, Jupiter, FL, United States., Lecka-Czernik B; Department of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.; Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.

Publikováno v: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Apr 18; Vol. 14, pp. 1145467. Date of Electronic Publication: 2023 Apr 18 (Print Publication: 2023).