Zobrazeno 1 - 10
of 888
pro vyhledávání: '"PPAR-α"'
Autor:
Motahareh Taghizadeh, Mohammad Hasan Maleki, Omid Vakili, Ramin Tavakoli, Parvin Zarei, Amirreza Dehghanian, Hossein Bordbar, Sayed Mohammad Shafiee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disorder characterized by fatty liver disease alongside overweight or obesity and/or type 2 diabetes mellitus (T2DM). Timely intervention is crucial for a potential cure. Th
Externí odkaz:
https://doaj.org/article/08a4871df48746b79fad544c9a385c6e
Autor:
Tie Hu, Wen-peng Yu, Xiu-qi Wang, Zi-yao Wang, Zhi-qiang Xu, Fa-jia Hu, Ji-chun Liu, Fan Yu, Li-jun Wang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract This study aimed to explore the effects of peroxisome proliferator-activated receptor α (PPAR-α), a known inhibitor of ferroptosis, in Myocardial ischemia/reperfusion injury (MIRI) and its related mechanisms. In vivo and in vitro MIRI mode
Externí odkaz:
https://doaj.org/article/2f1d8ba888b141c8b886a8f867f9151e
Publikováno v:
Journal of Functional Foods, Vol 122, Iss , Pp 106483- (2024)
This study was amied to explore the molecular mechanisms of the effect of pear pomace soluble dietary fiber (PP-SDF) on weight gain, fat deposition and regulation of lipid metabolism in obese mice. The PP-SDF can positively modulate the adverse effec
Externí odkaz:
https://doaj.org/article/7acb2bf50a714913be1105ee83b7a519
Publikováno v:
Current Research in Physiology, Vol 8, Iss , Pp 100133- (2025)
Chronic kidney disease (CKD) is a major risk factor for death in adults. Inflammation plays a role in the pathogenesis of CKD, but the mechanisms are poorly understood. Peroxisome proliferator-activated receptor alpha (PPAR-α) is a nuclear receptor
Externí odkaz:
https://doaj.org/article/12d8bf58cd5549148e558934891c24ce
Autor:
Al-Mazroua, Haneen A. a, Nadeem, Ahmed a, Attia, Sabry M. a, Bakheet, Saleh A. a, Ahmad, Ajaz b, Ansari, Mushtaq A. a, Ibrahim, Khalid E. c, Alomar, Hatun A. a, Almutairi, Mohammed M. a, Algarzae, Norah K. d, Mahmoud, Mohamed A. a, Hussein, Marwa H. a, Ahmed, Omer M. a, Ahmad, Sheikh F. a, ⁎
Publikováno v:
In International Immunopharmacology 3 January 2025 145
Autor:
Danila Di Majo, Nicolò Ricciardi, Alessandra Moncada, Mario Allegra, Monica Frinchi, Valentina Di Liberto, Rosa Pitonzo, Francesca Rappa, Filippo Saiano, Filippo Vetrano, Alessandro Miceli, Giuseppe Giglia, Giuseppe Ferraro, Pierangelo Sardo, Giuditta Gambino
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1324 (2024)
Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT’s antioxidant properties and its positive effects on metabo
Externí odkaz:
https://doaj.org/article/7c43cd81baf24b87a0a6fccab071d608
Autor:
Kohei Matsuta, Kazuko Kamiyama, Toru Imamoto, Izumi Takeda, Shinya Masunaga, Mamiko Kobayashi, Naoki Takahashi, Kenji Kasuno, Masanori Hara, Masayuki Iwano, Tadashi Toyama, Hideki Kimura
Publikováno v:
Cells, Vol 13, Iss 17, p 1446 (2024)
Peroxisome proliferator-activated receptor-alpha (PPAR-α) and its exogenous activators (fibrates) promote autophagy. However, whether the deleterious effects of PPAR-α deficiency on doxorubicin (DOX)-induced podocytopathy are associated with reduce
Externí odkaz:
https://doaj.org/article/07ab882f8c5f443ba901c93136fa4251
Publikováno v:
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad., Vol 67, Iss 2 (2024)
مقدمه: مقاومت به انسولین (IR) از مهمترین عوامل ایجادکننده اختلالات کبدی مشخص شده و با کاهش بیان گیرندۀ فعالشده با تکثیر پرواکسیزوم آلفا (PP
Externí odkaz:
https://doaj.org/article/f34c76af582e4defb61db2bd58f0d639
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101400- (2024)
Hypolipidemic and hepatoprotective effectives of the newly synthesized guaiacol-based fibrate derivatives were evaluated in Triton WR-1339-induced hyperlipidemic mice. All the target compounds were preliminary screened, in which compound T5 showed si
Externí odkaz:
https://doaj.org/article/3024691bf09b4b59b7566b79750f3b73
Autor:
Zehong Yang, Yuanyuan Yu, Nannan Sun, Limian Zhou, Dong Zhang, HaiXin Chen, Wei Miao, Weihang Gao, Canyang Zhang, Changhui Liu, Xiaoying Yang, Xiaojie Wu, Yong Gao
Publikováno v:
Journal of Ginseng Research, Vol 47, Iss 3, Pp 376-384 (2023)
Background: Hepatic lipid disorder impaired mitochondrial homeostasis and intracellular redox balance, triggering development of non-alcohol fatty liver disease (NAFLD), while effective therapeutic approach remains inadequate. Ginsenosides Rc has bee
Externí odkaz:
https://doaj.org/article/a069c7013b5c4d4c95bf30234b053e01