TRPML1 Participates in the Progression of Alzheimer’s Disease by Regulating the PPARγ/AMPK/Mtor Signalling Pathway

Autor: Lu Zhang, Yu Fang, Xuan Cheng, Yajun Lian, Hongliang Xu, Zhaoshu Zeng, Hongcan Zhu

Publikováno v: Cellular Physiology and Biochemistry, Vol 43, Iss 6, Pp 2446-2456 (2017)

Background: TRPML1 is reported to be involved in the pathogenesis of Alzheimer’s disease (AD) by regulating autophagy; however, the underlying mechanism is not completely clear. Methods: We developed an APP/PS1 transgenic animal model that presents

Externí odkaz: https://doaj.org/article/5ae631666f784fd09edcea6222135d55

TRPML1 Participates in the Progression of Alzheimer's Disease by Regulating the PPARγ/AMPK/Mtor Signalling Pathway.

Autor: Zhang L; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Fang Y; Department of Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Cheng X; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Lian Y; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Xu H; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Zeng Z; Department of Legal Medicine, The College of Basic Medical Sciences of Zhengzhou University, Zhengzhou, China., Zhu H; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2017; Vol. 43 (6), pp. 2446-2456. Date of Electronic Publication: 2017 Oct 31.