Výsledky vyhledávání - "PPARγ, peroxisome proliferator activated receptor gamma"

Akademický článek

PPARγ gene expression analysis in psoriasis treatment

Autor: V. V. Sobolev, A. G. Soboleva, N. N. Potekaev, O. O. Melnichenko, I. M. Korsunskaya, S. I. Artemyeva

Publikováno v: Медицинский совет, Vol 0, Iss 8, Pp 82-87 (2021)

Introduction. PPARγ is the most studied PPAR subtype and is expressed predominantly in adipose tissue, heart, colon, kidney, spleen, intestine, skeletal muscle, liver, macrophages, and skin. In the skin, PPARγ controls the genetic regulation of gen

Externí odkaz: https://doaj.org/article/b1f0ccb5546943e1bfd1e3e6afe06ba3

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Akademický článek

Common Variation in EDN1 Regulatory Regions Highlights the Role of PPARγ as a Key Regulator of Endothelin in vitro

Autor: Mauro Lago-Docampo, Carlos Solarat, Luis Méndez-Martínez, Adolfo Baloira, Diana Valverde

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Pulmonary Arterial Hypertension (PAH) is a rare disease caused by the obliteration of the pulmonary arterioles, increasing pulmonary vascular resistance and eventually causing right heart failure. Endothelin-1 (EDN1) is a vasoconstrictor peptide whos

Externí odkaz: https://doaj.org/article/0d4909038dc14a539676e321c75126e3

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Akademický článek

Crtc1 Deficiency Causes Obesity Potentially via Regulating PPARγ Pathway in White Adipose

Autor: Yimeng Hu, Jian Lv, Yu Fang, Qiang Luo, Yuan He, Lili Li, Mingxia Fan, Zhihua Wang

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Obesity is characterized by excessive fat accumulation and associated with glucose and lipid metabolism disorders. Crtc1, a transcription cofactor regulating CREB activity, has been involved in the pathogenesis of metabolic syndrome; however, the und

Externí odkaz: https://doaj.org/article/1c0069fb67f2467c937571dd25f30b8f

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β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway

Autor: Tomomi Minato, Nobuhisa Nakamura, Tomokazu Saiki, Megumi Miyabe, Mizuho Ito, Tatsuaki Matsubara, Keiko Naruse

Publikováno v: IBRO Neuroscience Reports
IBRO Neuroscience Reports, Vol 12, Iss, Pp 65-72 (2022)

β-Aminoisobutyric acid (BAIBA) is a myokine that is secreted from skeletal muscles by the exercise. Recently, increasing evidence has suggested the multifocal physiological activities of BAIBA. In this study, we investigated whether L-BAIBA has prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b998bc57e7f2d0b2c72bfab5039075a5
http://europepmc.org/articles/PMC8724974

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STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications

Autor: David A. Frank, Isidora Tošić

Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc1e221705a2edcb47149735290583
http://europepmc.org/articles/PMC8569436

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Hepatocyte-Specific Loss of PPARγ Protects Mice From NASH and Increases the Therapeutic Effects of Rosiglitazone in the Liver

Autor: Brian T. Layden, Samuel M Lee, Carolina M. Pusec, Andre Sarmento-Cabral, Grace Guzman, Jose Muratalla, Jose Cordoba-Chacon, Alberto Diaz-Ruiz, Gregory H Norris, Adam De Jesus

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1291-1311 (2021)

Background & Aims Nonalcoholic steatohepatitis (NASH) is commonly observed in patients with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for NASH. Although TZD increase insulin sensitivity and partially reduce stea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64e6962687742a800c78603d9395653
https://doi.org/10.1016/j.jcmgh.2021.01.003

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CXCL5 secreted from macrophages during cold exposure mediates white adipose tissue browning

Autor: Dabin Lee, Je-Yoel Cho, Sang-Hyuk Yoon, Yeo-Dae Yoon, Ki-Hoan Nam, A-Reum Nam, Sang-Mi Cho, Dong Wook Kim, Kang-Hoon Lee

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100117-(2021)

Adipose tissue affects metabolic-related diseases because it consists of various cell types involved in fat metabolism and adipokine release. CXC ligand 5 (CXCL5) is a member of the CXC chemokine family and is highly expressed by macrophages in white

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da49c0f843db52c4ce8936a83244b67
http://europepmc.org/articles/PMC8512628

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The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes

Autor: Hong-Ti Jia, Ju-Hua Ni, Guo-Shun An, Xinning Zhang, Xin Li

Publikováno v: The Journal of Biological Chemistry

Mitochondrial biogenesis and energy metabolism are essential for regulating the inflammatory state of monocytes. This state is partially controlled by peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), a coactivator that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5a737a61216099b15e0cf529d0de75
http://europepmc.org/articles/PMC8406003

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