Zobrazeno 1 - 10
of 1 939
pro vyhledávání: '"POSITIVE ALLOSTERIC MODULATOR"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionThe α6 subunit-containing GABAA receptors (α6GABAARs) are highly expressed in the trigeminal ganglia (TG), the sensory hub of the trigeminovascular system (TGVS). Hypo-GABAergic transmission in the TG was reported to contribute to migra
Externí odkaz:
https://doaj.org/article/9ce24f26600c4d24bc37ede64fe6fd4a
Autor:
Hong-Wei Dong, Kelly Weiss, Kathryn Baugh, Mac J. Meadows, Colleen M. Niswender, Jeffrey L. Neul
Publikováno v:
Neurotherapeutics, Vol 21, Iss 4, Pp e00384- (2024)
Rett syndrome (RTT) is a neurodevelopmental disorder primarily caused by mutations in the X chromosome-linked gene Methyl-CpG Binding Protein 2 (MECP2). Restoring MeCP2 expression after disease onset in a mouse model of RTT reverses phenotypes, provi
Externí odkaz:
https://doaj.org/article/662280363bb541b78198ddb9e19cb5b5
Autor:
Casey I. Gallagher, David P. Bishop, Thomas E. Lockwood, Tristan Rawling, Robert J. Vandenberg
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Zinc is a ubiquitous contaminant in many buffers, purified products and common labware that has previously been suggested to impact on the results of functional GlyR studies and may inadvertently cause the effectiveness of some GlyR modulators to be
Externí odkaz:
https://doaj.org/article/4d425daf67854576a2c4286ff073812a
Autor:
Fadime Canbolat, Nigar Kantarci-Carsibasi, Sevim Isik, Suhair Rami Mohammed Shamshir, Münteha Girgin
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 788-807 (2024)
Glutamate (Glu) toxicity has been an important research topic in toxicology and neuroscience studies. In vitro and in vivo studies have shown that Group II metabotropic Glu2 (mGlu2) activators have cell viability effects. This study aims to determine
Externí odkaz:
https://doaj.org/article/cf8c27840af140168fb82c319d01bc8f
Autor:
Jiahui Chen, Wenqing Ran, Yiman Huang, Junjie Wei, Jian Rong, Huiyi Wei, Yinlong Li, Guocong Li, Zhen Chen, Lee Collier, Nehal H. Elghazawy, Wolfgang Sippl, Ahmed Haider, Kai Liao, Chenchen Dong, Ying Li, Hao Xu, Wenpeng He, Lu Wang, Steven H. Liang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115842- (2023)
As a subclass of ionotropic glutamate receptors (iGluRs), α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors have been implicated in various neurological disorders and neurodegenerative diseases. To further our understanding of A
Externí odkaz:
https://doaj.org/article/0c8e3714e4864fda9db485416e7f5b4f
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 4, Pp 171-176 (2023)
ASP8062 is an orally available GABAB receptor positive allosteric modulator (PAM). This study assessed the potential of ASP8062 for treating opioid use disorder (OUD). Three rhesus monkeys were pretreated with ASP8062 (0.3, 1 or 3 mg/kg) by oral admi
Externí odkaz:
https://doaj.org/article/ed09f3019ecf440cb4dd646207ab770d
Autor:
Petrilla Jayaprakash, Dmytro Isaev, Keun-Hang Susan Yang, Rami Beiram, Murat Oz, Bassem Sadek
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 482 (2024)
Studying the involvement of nicotinic acetylcholine receptors (nAChRs), specifically α7-nAChRs, in neuropsychiatric brain disorders such as autism spectrum disorder (ASD) has gained a growing interest. The flavonoid apigenin (APG) has been confirmed
Externí odkaz:
https://doaj.org/article/bba029305b4c4ac9b0e217ca16ac2717
Publikováno v:
Brain Sciences, Vol 14, Iss 3, p 290 (2024)
Neuroinflammation contributes to the pathophysiology of major depressive disorder (MDD) by inducing neuronal excitability via dysregulation of microglial brain-derived neurotrophic factor (BDNF), Na-K-Cl cotransporter-1 (NKCC1), and K-Cl cotransporte
Externí odkaz:
https://doaj.org/article/35b99f6ecb68497f81edd174645be8c3
Autor:
Sachiko Nakakubo, Yasuyoshi Hiramatsu, Takeru Goto, Syuhei Kimura, Masashi Narugami, Midori Nakajima, Yuki Ueda, Hideaki Shiraishi, Atsushi Manabe, Dishary Sharmin, James M. Cook, Kiyoshi Egawa
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Dravet syndrome (DS) is an intractable epilepsy syndrome concomitant with neurodevelopmental disorder that begins in infancy. DS is dominantly caused by mutations in the SCN1A gene, which encodes the α subunit of a voltage-gated Na cha
Externí odkaz:
https://doaj.org/article/39e51f6b8f474a7f94e1feaa261f66f6
Autor:
Daniela G. Dengler, Qing Sun, Kaleeckal G. Harikumar, Laurence J. Miller, Eduard A. Sergienko
Publikováno v:
SLAS Discovery, Vol 27, Iss 7, Pp 384-394 (2022)
Obesity has become a prevailing health burden globally and particularly in the US. It is associated with many health problems, including cardiovascular disease, diabetes and poorer mental health. Hence, there is a high demand to find safe and effecti
Externí odkaz:
https://doaj.org/article/422a6a6075cb48808eb30e6c246e9ece