Zobrazeno 1 - 10
of 346
pro vyhledávání: '"PNPase"'
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-8 (2024)
Production and storage of synthetic mRNA can introduce a variety of byproducts which reduce the overall integrity and functionality of mRNA vaccines and therapeutics. mRNA integrity is therefore designated as a critical quality attribute which must b
Externí odkaz:
https://doaj.org/article/35a9f18a99204cc880a0c631d0e17b3a
Akademický článek
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Autor:
Seonha Park, Hyun Sook Kim, Kyuhyeon Bang, Ahreum Han, Byeongmin Shin, Minjeong Seo, Sulhee Kim, Kwang Yeon Hwang
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 621 (2024)
The exosome multiprotein complex plays a critical role in RNA processing and degradation. This system governs the regulation of mRNA quality, degradation in the cytoplasm, the processing of short noncoding RNA, and the breakdown of RNA fragments. We
Externí odkaz:
https://doaj.org/article/dd5118c8f98f476cbcad14202c5b2e9b
Publikováno v:
Continence, Vol 6, Iss , Pp 100699- (2023)
This review summarises the presentations during a workshop session entitled “The Use of Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia, Obstruction and Fibrosis – Mechanistic Concepts and Clinical Implications” at th
Externí odkaz:
https://doaj.org/article/c54b27fd5f5e4a0fb13b87227fbd6337
Autor:
Nan Wu, Yumeng Zhang, Shanshan Zhang, Youhua Yuan, Shuang Liu, Tao Xu, Peng Cui, Wenhong Zhang, Ying Zhang
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Despite the identification of many genes and pathways involved in the persistence phenomenon in bacteria, the mechanisms of persistence are not well understood. Here, using Escherichia coli, we identified polynucleotide phosphorylase (PNPase
Externí odkaz:
https://doaj.org/article/486cca2ee9ed45a2945d8d60c56706a1
Autor:
Juan C. Gonzalez-Rivera, Asuka A. Orr, Sean M. Engels, Joseph M. Jakubowski, Mark W. Sherman, Katherine N. O'Connor, Tomas Matteson, Brendan C. Woodcock, Lydia M. Contreras, Phanourios Tamamis
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 137-152 (2020)
The oxidation of RNA has been implicated in the development of many diseases. Among the four ribonucleotides, guanosine is the most susceptible to oxidation, resulting in the formation of 8-oxo-7,8-dihydroguanosine (8-oxoG). Despite the limited knowl
Externí odkaz:
https://doaj.org/article/82610a604a1949908969c643ec26f902
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT 8-Oxo-7,8-dihydroguanine (8-oxoG) is a major RNA modification caused by oxidative stresses and has been implicated in carcinogenesis, neurodegeneration, and aging. Several RNA-binding proteins have been shown to have a binding preference for
Externí odkaz:
https://doaj.org/article/1a38f37d680a4296be30a942f280b004
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background The polynucleotide phosphorylase (PNPase) is conserved among both Gram-positive and Gram-negative bacteria. As a core part of the Escherichia coli degradosome, PNPase is involved in maintaining proper RNA levels within the bacteri
Externí odkaz:
https://doaj.org/article/b69fe8439e17457c90c90b5bfb642389
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT The Bacillus subtilis genome encodes four 3′ exoribonucleases: polynucleotide phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Previous work showed that PNPase, encoded by the pnpA gene, is the major 3′ exonuclease involved in mRNA t
Externí odkaz:
https://doaj.org/article/4bfff2e6f17e44d68c5b4ed1d6b35d57
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Iron acquisition and modulation of its intracellular concentration are critical for the development of all living organisms. So far, several proteins have been described to be involved in iron homeostasis. Among them, ferritins act as the major iron
Externí odkaz:
https://doaj.org/article/1ef35f023e86429eba93e1fdfc9fd26b