Regulation of granulocyte-macrophage colony-stimulating factor and E- selectin expression in endothelial cells by cyclosporin A and the T- cell transcription factor NFAT

Autor: GW Cockerill, AG Bert, GR Ryan, JR Gamble, MA Vadas, PN Cockerill

Publikováno v: Blood. 86:2689-2698

Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29a2cb9f2f0ec0f2da8bf02a7ef8d084
https://doi.org/10.1182/blood.v86.7.2689.bloodjournal8672689

Regulation of GM-CSF gene transcription by core-binding factor

Autor: Pn, Cockerill, Cs, Osborne, Andrew Bert, Rj, Grotto

Publikováno v: Europe PubMed Central

GM-CSF gene activation in T cells is known to involve the transcription factors nuclear factor-kappa B, AP-1, NFAT, and Sp1. Here we demonstrate that the human GM-CSF promoter and enhancer also encompass binding sites for core-binding factor (CBF). S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::200e060de17f65a08e5a786ccb49ca08
http://europepmc.org/abstract/med/8809409

Gene regulatory network and signalling pathway rewiring: How blood cancer cells shift their shapes to evade drug treatment.

Autor: Bonifer C, Cockerill PN

Publikováno v: Oncotarget [Oncotarget] 2024 Oct 11; Vol. 15, pp. 714-716. Date of Electronic Publication: 2024 Oct 11.

Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth.

Autor: Kellaway SG; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. Sophie.Kellaway@nottingham.ac.uk.; Blood Cancer and Stem Cells, Centre for Cancer Sciences, School of Medicine, University of Nottingham, Nottingham, UK. Sophie.Kellaway@nottingham.ac.uk., Potluri S; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Keane P; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; School of Biosciences, University of Birmingham, Birmingham, UK., Blair HJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Ames L; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Worker A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Chin PS; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Ptasinska A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Derevyanko PK; Princess Maxima Center of Pediatric Oncology, Utrecht, Netherlands., Adamo A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Coleman DJL; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Khan N; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Assi SA; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Krippner-Heidenreich A; Princess Maxima Center of Pediatric Oncology, Utrecht, Netherlands., Raghavan M; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK., Cockerill PN; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Heidenreich O; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Princess Maxima Center of Pediatric Oncology, Utrecht, Netherlands., Bonifer C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. c.bonifer@bham.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 14; Vol. 15 (1), pp. 1359. Date of Electronic Publication: 2024 Feb 14.

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth.

Autor: Coleman DJL; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Keane P; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; School of Biosciences, University of Birmingham, Birmingham B15 2TT, U.K., Luque-Martin R; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Herschel Building, Level 6, Brewery Lane, Newcastle upon Tyne NE1 7RU, UK., Chin PS; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Blair H; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Herschel Building, Level 6, Brewery Lane, Newcastle upon Tyne NE1 7RU, UK., Ames L; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Kellaway SG; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Griffin J; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Holmes E; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Potluri S; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Assi SA; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Bushweller J; University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA., Heidenreich O; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Herschel Building, Level 6, Brewery Lane, Newcastle upon Tyne NE1 7RU, UK; Prinses Máxima Centrum for Pediatric Oncology, Postbus 113, 3720 AC Bilthoven, Heidelberglaan 25, 3584CS Utrecht, the Netherlands. Electronic address: o.t.heidenreich@prinsesmaximacentrum.nl., Cockerill PN; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: p.n.cockerill@bham.ac.uk., Bonifer C; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: c.bonifer@bham.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2023 Dec 26; Vol. 42 (12), pp. 113568. Date of Electronic Publication: 2023 Dec 15.