A Novel Recognition by the E3 Ubiquitin Ligase of HSV-1 ICP0 Enhances the Degradation of PML Isoform I to Prevent ND10 Reformation in Late Infection.

Autor: Jan Fada, Behdokht¹ (AUTHOR), Guha, Udayan¹ (AUTHOR), Zheng, Yi¹ (AUTHOR), Reward, Eleazar¹ (AUTHOR), Kaadi, Elie¹ (AUTHOR), Dourra, Ayette¹ (AUTHOR), Gu, Haidong¹ (AUTHOR) haidong.gu@wayne.edu

Publikováno v: Viruses (1999-4915). May2023, Vol. 15 Issue 5, p1070. 23p.

PML isoform expression and DNA break location relative to PML nuclear bodies impacts the efficiency of homologous recombination.

Autor: Attwood, Kathleen M.¹, Salsman, Jayme², Chung, Dudley^1,2, Mathavarajah, Sabateeshan², Van Iderstine, Carter², Dellaire, Graham^1,2 dellaire@dal.ca

Publikováno v: Biochemistry & Cell Biology. Jun2020, Vol. 98 Issue 3, p314-326. 13p.

Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection.

Autor: Jan Fada B; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA., Kaadi E; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA., Samrat SK; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA., Zheng Y; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA., Gu H; Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA haidong.gu@wayne.edu.

Publikováno v: Journal of virology [J Virol] 2020 Jun 01; Vol. 94 (12). Date of Electronic Publication: 2020 Jun 01 (Print Publication: 2020).

Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection

Autor: Haidong Gu, Behdokht Jan Fada, Elie Kaadi, Yi Zheng, Subodh Kumar Samrat

Publikováno v: J Virol

ND10 nuclear bodies, as part of the intrinsic defenses, impose repression on incoming DNA. Infected cell protein 0 (ICP0), an E3 ubiquitin ligase of herpes simplex virus 1 (HSV-1), can derepress viral genes by degrading ND10 organizers to disrupt ND1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e844accd11f453b1abd63702e5df18
https://doi.org/10.1128/jvi.00470-20

PML isoform expression and DNA break location relative to PML nuclear bodies impacts the efficiency of homologous recombination

Autor: Graham Dellaire, Sabateeshan Mathavarajah, Carter Van Iderstine, Kathleen M. Attwood, Jayme Salsman, Dudley Chung

Publikováno v: Biochemistry and cell biology = Biochimie et biologie cellulaire. 98(3)

Promyelocytic leukemia nuclear bodies (PML NBs) are nuclear subdomains that respond to genotoxic stress by increasing in number via changes in chromatin structure. However, the role of the PML protein and PML NBs in specific mechanisms of DNA repair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f670f21d065ade6e4403ff50ef26a55
https://pubmed.ncbi.nlm.nih.gov/31671275