Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

Autor: Mollereau, B., Rzechorzek, N. M., Roussel, B. D., Sedru, M., Brink, D., Bailly-Maitre, B., Palladino, F., Medinas, D. B., Domingos, P. M., Hunot, S., Chandran, S., Birman, S., Baron, T., Vivien, D., Duarte, C. B., Ryoo, H. D., Steller, H., Urano, F., Chevet, E., Kroemer, G., Ciechanover, A., Calabrese, E. J., Kaufman, R. J., Hetz, C

Publikováno v: Brain Research
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. 〈10.1016/j.brainres.2016.02.033〉
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. ⟨10.1016/j.brainres.2016.02.033⟩
Mollereau, B, Rzechorzek, N M, Roussel, BD, Sedru, M, Van denBrink, D, Bailly-Maitre, B, Palladino, F, Medinas, DB, Domingos, PM, Hunot, S, Chandran, S, Birman, S, Baron, T, Vivien, D, Duarte, CB, Ryoo, HD, Steller, H, Urano, F, Chevet, E, Kroemer, G, Ciechanover, A, Calabrese, EJ, Kaufman, RJ & Hetz, C 2016, ' Adaptive preconditioning in neurological diseases-­ therapeutic insights from proteostatic perturbations ', Brain Research . https://doi.org/10.1016/j.brainres.2016.02.033

In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac2c955da4a10f0f472d98f9cd8189b5
http://europepmc.org/articles/PMC5010532