Zobrazeno 1 - 10
of 39
pro vyhledávání: '"PMA, Phorbol Myristate Acetate"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)
Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 inflammasome has been considered to be a potential therapy, the underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b197d7e1bd61447a9d7a45da0a56387
https://doi.org/10.1016/j.apsb.2021.03.011
https://doi.org/10.1016/j.apsb.2021.03.011
Autor:
Alexey A. Martyanov, Anna E. Boldova, Maria G. Stepanyan, Olga I. An, Alexander S. Gur'ev, Darya V. Kassina, Alexey Y. Volkov, Alexandr V. Balatskiy, Andrei A. Butylin, Sergei S. Karamzin, Elena V. Filimonova, Sergei V. Tsarenko, Sergei A. Roumiantsev, Alexander G. Rumyantsev, Mikhail A. Panteleev, Fazoil I. Ataullakhanov, Anastasia N. Sveshnikova
Publikováno v:
Thrombosis Research
Introduction Defects of platelet functional responses in COVID-19 were reported, but their origin and pathophysiological significance are unclear. The objective of this study was to characterize the thrombocytopathy in COVID-19. Materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09171bc1034192e225b611aa23b08352
https://pubmed.ncbi.nlm.nih.gov/35066204
https://pubmed.ncbi.nlm.nih.gov/35066204
Autor:
Alessandra Eva, Paola Marcolongo, Roberta Resaz, Chiara Lavarello, Simonetta Astigiano, Maria Veiga-da-Cunha, Daniela Melis, Federica Raggi, Antonia Assunto, Andrea Petretto, Alessandra Gamberucci, Maria Carla Bosco, Daniela Segalerba, Francesco Trepiccione, Mariavittoria D'Acierno
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 29, Iss, Pp 100813-(2021)
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports
Glycogen Storage Disease type 1b (GSDIb) is a genetic disorder with long term severe complications. Accumulation of the glucose analog 1,5-anhydroglucitol-6-phosphate (1,5AG6P) in neutrophils inhibits the phosphorylation of glucose in these cells, ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a972cc08490cef934144a4ec91b7f7
http://hdl.handle.net/11386/4803796
http://hdl.handle.net/11386/4803796
Autor:
Allison C. Provost, Andreas Jeromin, Nikolaos P. Daskalakis, Lauren E. Chaby, Heather Lasseter, Magali Haas
Publikováno v:
Cytokine
Cytokine: X, Vol 2, Iss 2, Pp 100027-(2020)
Cytokine: X, Vol 2, Iss 2, Pp 100027-(2020)
Highlights • Cross-platform comparisons were conducted across five leading immunoassay platforms. • Plasma and serum were obtained from healthy controls and clinical populations. • Analytic parameters included sensitivity, precision, and perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290352d998ae54423228c23c650bc1fb
http://europepmc.org/articles/PMC7885879
http://europepmc.org/articles/PMC7885879
Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation
Autor:
Justin A. MacDonald, Catherine J. Greene, Christina F. Sandall, Neil McKenna, Rhiannon I. Campden, Jose A. Chiriboga, Robin M. Yates, Devin Aggarwal, Amy L. Warren, Corey R. Arnold
Publikováno v:
The Journal of Biological Chemistry
Respiratory silicosis is a preventable occupational disease that develops secondary to the aspiration of crystalline silicon dioxide (silica) into the lungs, activation of the NLRP3 inflammasome, and IL-1β production. Cathepsin Z has been associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b27c210c61616d4955d5ffecfb0fa14
https://doi.org/10.1016/j.jbc.2021.101459
https://doi.org/10.1016/j.jbc.2021.101459
Autor:
Haleh Davanian, Margaret Chen, Soo Aleman, Anthony T. Tan, Katie Healy, Antonio Bertoletti, Andrea Pavesi, Tiphaine Parrot, Johan K. Sandberg, Susanne E Reinsbach, Michał J. Sobkowiak
Publikováno v:
JHEP Reports, Vol 3, Iss 4, Pp 100318-(2021)
JHEP Reports
JHEP Reports
Background & Aims Virus-specific T cell dysfunction is a common feature of HBV-related hepatocellular carcinoma (HBV-HCC). Conventional T (ConT) cells can be redirected towards viral antigens in HBV-HCC when they express an HBV-specific receptor; how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd0342307cbb74465ae0246e43031e6
https://doi.org/10.1016/j.jhepr.2021.100318
https://doi.org/10.1016/j.jhepr.2021.100318
Publikováno v:
The Journal of Biological Chemistry
NADPH oxidase 2 (NOX2) produces the superoxide anion radical (O2−), which has functions in both cell signaling and immune defense. NOX2 is a multimeric-protein complex consisting of several protein subunits including the GTPase Rac. NOX2 uniquely f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1acf3cfb40506c59e24d46a27b8069
https://doi.org/10.1016/j.jbc.2021.100982
https://doi.org/10.1016/j.jbc.2021.100982
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 147-153 (2017)
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 147-153 (2017)
Formation of neutrophil extracellular traps (NETs) can perpetuate sterile inflammation; thus, it is important to clarify their pathophysiological characteristics. Free heme, derived via hemolysis, is a major contributor to organ damage, and reportedl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49aed49a90a202ef4b9d86ead66d7148
http://europepmc.org/articles/PMC5614717
http://europepmc.org/articles/PMC5614717
Autor:
Leila Roshangar, Samaneh Abdolmohammadi-Vahid, Mehmet Ziya Gencer, Sepehr Valizadeh, Ali Ammari, Armin Sadeghi, Saeed Aslani, Mahnaz Ghaebi, Svetlana Danshina, Hamed Valizadeh, Majid Ahmadi, Abdolreza Esmaeilzadeh
Publikováno v:
International Immunopharmacology
Background As an ongoing worldwide health issue, Coronavirus disease 2019 (COVID–19) has been causing serious complications, including pneumonia, acute respiratory distress syndrome (ARDS), and multi-organ failure. However, there is no decisive tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d2923b1116046882f097b81c1e1453
https://doi.org/10.1016/j.intimp.2020.107088
https://doi.org/10.1016/j.intimp.2020.107088
Autor:
Aulus Cavalieri Carciofi, Márcio Antônio Brunetto, Fernanda Sant Anna Kroll, Thiago Henrique Annibale Vendramini, Vivian Pedrinelli, Thaila Cristina Putarov, João Paulo Fernandes Santos, K.S. Venturini, C.G. Aoki, Leandro Zaine
Publikováno v:
Animal Feed Science and Technology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Highlights • Aging can promote changes in the immune system in dogs. • Nutritional intervention in older dogs aims to increase lifespan. • The yeast cell wall comprises β-(1,3)-D-glucan, β-(1,6)-D-glucan and mannoproteins. • Elderly dogs wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034caea89af5a9d0cd67dbed02042412
https://pubmed.ncbi.nlm.nih.gov/32288071
https://pubmed.ncbi.nlm.nih.gov/32288071