BGC20-1531, a novel, potent and selective prostanoid EP4 receptor antagonist: a putative new treatment for migraine headache

Autor: Robert A. Coleman, PM Lockey, DE Clark, AW Oxford, KA Maubach, G Fenton, Kenneth L. Clark, R.M. Hagan, RJ Davis, C Routledge

Background and purpose: Prostanoid EP4 receptor antagonists may have therapeutic utility in the treatment of migraine since EP4 receptors have been shown to be involved in prostaglandin (PG)E2-induced cerebral vascular dilatation, which may be an imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff57c78a0231fd0a521e6676b395e9a8
https://europepmc.org/articles/PMC2697835/

An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.

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Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.

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BGC20-1531, a novel, potent and selective prostanoid EP receptor antagonist: a putative new treatment for migraine headache.

Autor: Maubach KA; BTG International Ltd., 10 Fleet Place, Limeburner Lane, London, UK. karen.maubach@btgplc.com, Davis RJ, Clark DE, Fenton G, Lockey PM, Clark KL, Oxford AW, Hagan RM, Routledge C, Coleman RA

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