beta-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation.

Autor: WM Holleran, Y Takagi, G Imokawa, S Jackson, JM Lee, PM Elias

Publikováno v: Journal of Lipid Research, Vol 33, Iss 8, Pp 1201-1209 (1992)

The intercellular lipids of the stratum corneum, which are highly enriched in ceramides, are critical for the mammalian epidermal permeability barrier. During the terminal stages of epidermal differentiation, the glucosylceramide content is dramatica

Externí odkaz: https://doaj.org/article/6fe0ddc45505483d9c2fa41240fd762e

Serine-palmitoyl transferase activity in cultured human keratinocytes

Autor: WM Holleran, ML Williams, WN Gao, PM Elias

Publikováno v: Journal of Lipid Research, Vol 31, Iss 9, Pp 1655-1661 (1990)

Sphingolipids comprise approximately 25% of the stratum corneum lipids and are considered critical constituents of the epidermal permeability barrier. Whether sphingoid base structures are synthesized in the epidermis or whether they are derived from

Externí odkaz: https://doaj.org/article/22cfa0a326d1469fa2639a9b6e79e84d

Sphingosine-1-Phosphate-Cathelicidin Axis Plays a Pivotal Role in the Development of Cutaneous Squamous Cell Carcinoma.

Autor: Park K; Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea; Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA. Electronic address: Kyungho.Park@hallym.ac.kr., Shin KO; Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea; Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea; LaSS, Chuncheon, Republic of Korea., Kim YI; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA., Nielsen-Scott AL; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA., Mainzer C; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA., Celli A; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA., Bae Y; Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea; Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea., Chae S; Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea; Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea., An H; Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea; Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea., Choi Y; Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea; Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea; LaSS, Chuncheon, Republic of Korea., Park JH; Personalized Diet Research Group, Korea Food Research Institute, Jeonju, Republic of Korea., Park SH; Personalized Diet Research Group, Korea Food Research Institute, Jeonju, Republic of Korea., Hwang JT; Personalized Diet Research Group, Korea Food Research Institute, Jeonju, Republic of Korea; Department of Food Biotechnology, University of Science and Technology, Daejeon, Republic of Korea., Kang SG; Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon, Republic of Korea., Wakefield JS; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA., Arron ST; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA., Holleran WM; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA., Mauro TM; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA., Elias PM; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA., Uchida Y; Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea; Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea; Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA; San Francisco VA Medical Center, Northern California Institute for Research and Education, San Francisco, California, USA. Electronic address: Yoshikazu.Uchida@ucsf.edu.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2024 Aug 30. Date of Electronic Publication: 2024 Aug 30.

Skin Barrier in Atopic Dermatitis.

Autor: Schmuth M; Dermatology, Venerology and Allergy, Medical University Innsbruck, Innsbruck, Austria; Institute for Pediatric Dermatology and Rare Diseases, Karl Landsteiner Society, Innsbruck, Austria. Electronic address: matthias.schmuth@i-med.ac.at., Eckmann S; Dermatology, Venerology and Allergy, Medical University Innsbruck, Innsbruck, Austria., Moosbrugger-Martinz V; Dermatology, Venerology and Allergy, Medical University Innsbruck, Innsbruck, Austria., Ortner-Tobider D; Dermatology, Venerology and Allergy, Medical University Innsbruck, Innsbruck, Austria., Blunder S; Dermatology, Venerology and Allergy, Medical University Innsbruck, Innsbruck, Austria., Trafoier T; Dermatology, Venerology and Allergy, Medical University Innsbruck, Innsbruck, Austria., Gruber R; Dermatology, Venerology and Allergy, Medical University Innsbruck, Innsbruck, Austria; Institute for Pediatric Dermatology and Rare Diseases, Karl Landsteiner Society, Innsbruck, Austria., Elias PM; Dermatology, Veteran Affairs Health Care System, San Francisco, California, USA; University of California San Francisco, San Francisco, California, USA.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2024 May; Vol. 144 (5), pp. 989-1000.e1.

"Outside-to-inside," "inside-to-outside," and "intrinsic" endogenous pathogenic mechanisms in atopic dermatitis: keratinocytes as the key functional cells involved in both permeability barrier dysfunction and immunological alterations.

Autor: Hatano Y; Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan., Elias PM; Department of Dermatology, University of California, San Francisco and Veterans Affairs Health Care System, San Francisco, CA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Aug 11; Vol. 14, pp. 1239251. Date of Electronic Publication: 2023 Aug 11 (Print Publication: 2023).