Preclinical evaluation of the abuse potential of Pitolisant, a histamine H3receptor inverse agonist/antagonist compared with Modafinil

Autor: M Uguen, PM Beardsley, Xavier Ligneau, Jeanne-Marie Lecomte, Perrin David, S Belliard, J.-C. Schwartz

Publikováno v: British Journal of Pharmacology. 169:632-644

Background and Purpose Pitolisant, a histamine H3 receptor inverse agonist/antagonist is currently under Phase III clinical trials for treatment of excessive daytime sleepiness namely in narcoleptic patients. Its drug abuse potential was investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a226bc770e15256b94cfb13032769e8
https://doi.org/10.1111/bph.12149

Enantiomeric contributions to methamphetamine's bidirectional effects on basal and fentanyl-depressed respiration in mice.

Autor: Elder HJ; Now at Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Pharmacology & Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. Electronic address: helder2@jhmi.edu., Walentiny DM; Department of Pharmacology & Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Beardsley PM; Department of Pharmacology & Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Center for Biomarker Research & Precision Medicine, Virginia Commonwealth University School of Pharmacy, Richmond, VA, USA.

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Structurally diverse fentanyl analogs yield differential locomotor activities in mice.

Autor: Varshneya NB; Center for Drug Evaluation and Research, Food and Drug Administration, United States Department of Health and Human Services, Silver Spring, MD, USA; Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. Electronic address: nvarshn2@jhmi.edu., Walentiny DM; Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Stevens DL; Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Walker TD; Diversion Control Division, Drug Enforcement Administration, United States Department of Justice, Springfield, VA, USA., Akinfiresoye LR; Diversion Control Division, Drug Enforcement Administration, United States Department of Justice, Springfield, VA, USA., Beardsley PM; Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Center for Biomarker Research & Precision Medicine, Virginia Commonwealth University School of Pharmacy, Richmond, VA, USA.

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