Polymeric nanoparticles for co-delivery of synthetic long peptide antigen and poly IC as therapeutic cancer vaccine formulation

Autor: Rahimian, Sima, Fransen, Marieke F., Kleinovink, Jan Willem, Christensen, Jonatan Riis, Amidi, Maryam, Hennink, Wim E., Ossendorp, Ferry, Sub Drug delivery, UIPS - Utrecht Institute for Pharmaceutical Sciences, Sub Drug targeting, Pharmaceutics

Publikováno v: Journal of Controlled Release, 203, 16-22
Journal of Controlled Release, 203, 16. Elsevier

The aim of the current study was to develop a cancer vaccine formulation for treatment of human papillomavirus (HPV)-induced malignancies. Synthetic long peptides (SLPs) derived from HPV16 E6 and E7 oncoproteins have been used for therapeutic vaccina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2d10638a6bc15a6784b307e2a1f92b
https://doi.org/10.1016/j.jconrel.2015.02.006

Polymeric microspheres for local delivery of proteins by administration under the kidney capsule

Acute kidney injury and chronic kidney disease are conditions characterized by the inability of the kidneys to adequately filter waste products from the blood. The most common treatment remains renal replacement therapy (dialysis and renal transplant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::884c2b2cc0d956b9d16838345cdbe749
https://hdl.handle.net/1874/320059

Biocompatibility of poly(D,L-lactic-co-hydroxymethyl glycolic acid) microspheres after subcutaneous and subcapsular renal injection

Autor: Kazazi-Hyseni, F., Zandstra, J., Popa, E. R., Goldschmeding, R., Lathuile, A. A R, Veldhuis, G. J., Van Nostrum, C. F., Hennink, W. E., Kok, R. J., Sub Drug delivery, Pharmaceutics

Publikováno v: International Journal of Pharmaceutics, 482(1-2), 99. Elsevier bedrijfsinformatie b.v.
International Journal of Pharmaceutics, 482(1-2), 99. Elsevier
International Journal of Pharmaceutics, 482(1-2), 99-109. Elsevier Bedrijfsinformatie b.v.

Poly(D,L-lactic-co-hydroxymethyl glycolic acid) (PLHMGA) is a biodegradable copolymer with potential as a novel carrier in polymeric drug delivery systems. In this study, the biocompatibility of PLHMGA microspheres (PLHMGA-ms) was investigated both i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9584eb6a7764dc173e7cecef10c68cf
https://pubmed.ncbi.nlm.nih.gov/25497444

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