Zobrazeno 1 - 10
of 187
pro vyhledávání: '"PLCG1"'
Publikováno v:
European Journal of Translational Myology (2024)
Papillary thyroid carcinoma is an epithelial malignancy with follicular cell differentiation and sets of defined nuclear features and appearance of an irregular solid mass. The main objective of our study is to research on the expression of miR-218-2
Externí odkaz:
https://doaj.org/article/ce0c2d022b604fb388c1961deb931ebd
Autor:
Edhriz Siraliev-Perez, Jordan TB Stariha, Reece M Hoffmann, Brenda RS Temple, Qisheng Zhang, Nicole Hajicek, Meredith L Jenkins, John E Burke, John Sondek
Publikováno v:
eLife, Vol 11 (2022)
Numerous receptor tyrosine kinases and immune receptors activate phospholipase C-γ (PLC-γ) isozymes at membranes to control diverse cellular processes including phagocytosis, migration, proliferation, and differentiation. The molecular details of t
Externí odkaz:
https://doaj.org/article/6823aa70d66242049c851323e1518a22
Autor:
Masayuki Shiseki, Mayuko Ishii, Mari Miyazaki, Satoko Osanai, Yan‐Hua Wang, Kentaro Yoshinaga, Naoki Mori, Junji Tanaka
Publikováno v:
Cancer Medicine, Vol 9, Iss 2, Pp 460-468 (2020)
Abstract The PLCG1 gene, which encodes the phospholipase C γ1 isoform, is located within the commonly deleted region of the long arm of chromosome 20 (del(20q)) observed in myelodysplastic syndromes (MDS). Phospholipase C is involved in diverse phys
Externí odkaz:
https://doaj.org/article/e7059046425c4fd9a85dbfb08bc2d4d5
Akademický článek
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Akademický článek
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Autor:
Kiera Walker, Nathaniel H. Boyd, Joshua C. Anderson, Christopher D. Willey, Anita B. Hjelmeland
Publikováno v:
Biomarker Research, Vol 6, Iss 1, Pp 1-9 (2018)
Abstract Background For glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model physiologic levels, nor
Externí odkaz:
https://doaj.org/article/57c3f77f24544eada62c4a8c6e83e0d3
Akademický článek
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Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Gliomas are the most common and recalcitrant intracranial tumors, approximately a quarter of which are classified as lower-grade gliomas (WHO II–III). Although the prognosis of lower-grade gliomas (LGGs) is significantly better than that of higher-
Publikováno v:
Cancer Res
Small cell lung cancer (SCLC) remains a recalcitrant disease where limited therapeutic options have not improved overall survival, and approved targeted therapies are lacking. Amplification of the tyrosine kinase receptor FGFR1 (fibroblast growth fac
Autor:
Steven W. Lane, Florian Perner, Nicolas Huber, Florian H. Heidel, Elizabeth Ng, Andreas Hochhaus, Edouard G. Stanley, Zhu Chen, Chen-Jen Hsu, Monica Nafria, Ashok Kumar Jayavelu, Lars Bullinger, Lu Jiang, Klaus-Dieter Fischer, Constanze Bonifer, Matthias Mann, Marcus Buschbeck, Steffen Brodt, Holger Bierhoff, Tina M. Schnoeder, Adrian Schwarzer, Sai-Juan Chen, Joanna Kirkpatrick, Georg Matziolis, Olaf Heidenreich, Patricia Arreba-Tutusaus, Theresa Eifert, Björn von Eyss, Chun-Wei Chen, Konstanze Döhner, Andrew G. Elefanty, Anna Dolnik, Yuting Dai, Sophie G Kellaway, Anetta Ptasinska, Salam A. Assi, Alessandro Ori
Publikováno v:
Blood
In an effort to identify novel drugs targeting fusion-oncogene–induced acute myeloid leukemia (AML), we performed high-resolution proteomic analysis. In AML1-ETO (AE)-driven AML, we uncovered a deregulation of phospholipase C (PLC) signaling. We id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc5d880ca55311258241635b370c0f4
http://edoc.mdc-berlin.de/21022/1/21022oa.pdf
http://edoc.mdc-berlin.de/21022/1/21022oa.pdf