Zobrazeno 1 - 10
of 84
pro vyhledávání: '"PLC-γ1"'
Autor:
Helena M. Stricker, Nadine Rommerswinkel, Silvia Keil, Sandina A. Gnoth, Bernd Niggemann, Thomas Dittmar
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background Phosphotyrosine kinase (PTK)-mediated phospholipase C-γ1 (PLC-γ1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for several cellular process
Externí odkaz:
https://doaj.org/article/3f198aeb9e0b46f0960b6586c9f669b7
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The SUMO modification system plays an important role in T cell activation, yet how sumoylation regulates TCR-proximal signaling remains largely unknown. We show here that Phospholipase C-γ1 (PLC-γ1) is conjugated by SUMO1 at K54 and K987 upon TCR s
Externí odkaz:
https://doaj.org/article/efe9d211b7f748cd837f27df41f7ac3f
Autor:
Po-Sheng Yang, Meng-Jiy Wang, Thanasekaran Jayakumar, Duen-Suey Chou, Ching-Ya Ko, Ming-Jen Hsu, Cheng-Ying Hsieh
Publikováno v:
Molecules, Vol 20, Iss 5, Pp 8198-8212 (2015)
Abnormal proliferation of vascular smooth muscle cells (VSMCs) is important in the pathogenesis of vascular disorders such as atherosclerosis and restenosis. Hinokitiol, a tropolone derivative found in Chamacyparis taiwanensis, has been found to exhi
Externí odkaz:
https://doaj.org/article/9574e832182941cda812b854cce9abf7
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 8, Pp 13236-13246 (2014)
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation including extracellular matrix (ECM) degradation and cell loss. It is known that phosphoinositide-specific phospholipase γ1 (PLCγ1) can trigger sev
Externí odkaz:
https://doaj.org/article/d1a223f1102d4b8dbbf9acd41d1d2215
Autor:
Mahmood Yousif Bilal, Jon C.D. Houtman
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
GRB2 is a ubiquitously expressed adaptor protein required for signaling downstream of multiple receptors. To address the role of GRB2 in receptor-mediated signaling, the expression of GRB2 was suppressed in human CD4+ T cells and its role downstream
Externí odkaz:
https://doaj.org/article/733fe42c0e584a16afe722c943c0ddf1
Publikováno v:
International Journal of Biological Sciences, Vol 1, Iss 2, Pp 44-50 (2005)
PIKE (PI 3-Kinase Enhancer) is a recently identified brain specific nuclear GTPase, which binds PI 3-kinase and stimulates its lipid kinase activity. Nerve growth factor treatment leads to PIKE activation by triggering the nuclear translocation of ph
Externí odkaz:
https://doaj.org/article/20e22b21cb124db1ae7a67b0a953aaa4
Autor:
Nadine Rommerswinkel, Silvia Keil, Bernd Niggemann, Thomas Dittmar, Sandina A. Gnoth, Helena M. Stricker
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-16 (2021)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
BackgroundPhosphotyrosine kinase (PTK)-mediated phospholipase C-γ1 (PLC-γ1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for several cellular processes, includ
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.