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Monoclonal-Based Antivenomics Reveals Conserved Neutralizing Epitopes in Type I PLA2 Molecules from Coral Snakes

Autor: Carlos Corrêa-Netto, Marcelo A. Strauch, Marcos Monteiro-Machado, Ricardo Teixeira-Araújo, Juliana Guzzo Fonseca, Moema Leitão-Araújo, Maria Lúcia Machado-Alves, Libia Sanz, Juan J. Calvete, Paulo A. Melo, Russolina Benedeta Zingali

Publikováno v: Toxins, Vol 15, Iss 1, p 15 (2022)

For over a century, polyclonal antibodies have been used to treat snakebite envenoming and are still considered by the WHO as the only scientifically validated treatment for snakebites. Nevertheless, moderate innovations have been introduced to this

Externí odkaz: https://doaj.org/article/f5016d0aeb7746529b449b41ebe4b451

Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

Autor: Chunfang Xie, Laura-Oana Albulescu, Kristina B. M. Still, Julien Slagboom, Yumei Zhao, Zhengjin Jiang, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool

Publikováno v: Biomedicines, Vol 8, Iss 6, p 165 (2020)

Phospholipase A2 (PLA2) enzymes are important toxins found in many snake venoms, and they can exhibit a variety of toxic activities including causing hemolysis and/or anticoagulation. In this study, the inhibiting effects of the small molecule PLA2 i

Externí odkaz: https://doaj.org/article/b55a59bd56e14f879e316a41da2553ad

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Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

Autor: Julien Slagboom, Nicholas R. Casewell, Govert W. Somsen, Zhengjin Jiang, Freek J. Vonk, Yumei Zhao, Jeroen Kool, Laura-Oana Albulescu, Kristina B.M. Still, Chunfang Xie

Publikováno v: Biomedicines
Volume 8
Issue 6
Biomedicines, Vol 8, Iss 165, p 165 (2020)
Xie, C, Albulescu, L O, Still, K B M, Slagboom, J, Zhao, Y, Jiang, Z, Somsen, G W, Vonk, F J, Casewell, N R & Kool, J 2020, ' Varespladib inhibits the phospholipase A 2 and coagulopathic activities of venom components from hemotoxic snakes ', Biomedicines, vol. 8, no. 6, 165, pp. 1-17 . https://doi.org/10.3390/biomedicines8060165
Biomedicines, 8(6):165, 1-17. MDPI AG

Phospholipase A2 (PLA2) enzymes are important toxins found in many snake venoms, and they can exhibit a variety of toxic activities including causing hemolysis and/or anticoagulation. In this study, the inhibiting effects of the small molecule PLA2 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f876f0f58598a5e95659ee4aa142fa52