Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease

Autor: PL McCarthy, S Abhyankar, S Neben, G Newman, C Sieff, RC Thompson, SJ Burakoff, JL Ferrara

Publikováno v: Blood. 78:1915-1918

Graft-versus-host disease (GVHD) is the major complication of allogeneic bone marrow transplantation (BMT). Dysregulation of inflammatory monokines such as tumor necrosis factor alpha (TNF alpha) has been noted in both clinical and experimental GVHD.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c800867c967198ab353c8d39684b6952
https://doi.org/10.1182/blood.v78.8.1915.bloodjournal7881915

Minimal Residual Disease Status in Multiple Myeloma 1 Year After Autologous Hematopoietic Cell Transplantation and Lenalidomide Maintenance Are Associated With Long-Term Overall Survival.

Autor: Pasquini MC; Medical College of Wisconsin, Milwaukee, WI., Wallace PK; Roswell Park Comprehensive Cancer Center, Buffalo, NY., Logan B; Medical College of Wisconsin, Milwaukee, WI., Kaur M; Medical College of Wisconsin, Milwaukee, WI., Tario JD; Roswell Park Comprehensive Cancer Center, Buffalo, NY., Howard A; National Marrow Donor Program, Minneapolis, MN., Zhang Y; Roswell Park Comprehensive Cancer Center, Buffalo, NY., Brunstein C; University of Minnesota, Minneapolis, MN., Efebera Y; OhioHealth, Columbus, OH.; Ohio State University, Columbus, OH., Geller N; National Heart, Lung and Blood Institute, Bethesda, MD., Giralt S; Memorial Sloan Kettering Cancer Center, New York, NY., Hari P; Medical College of Wisconsin, Milwaukee, WI., Horowitz MM; Medical College of Wisconsin, Milwaukee, WI., Koreth J; Dana Farber Cancer Institute, Boston, MS., Krishnan A; City of Hope, Duarte, CA., Landau H; Memorial Sloan Kettering Cancer Center, New York, NY., Somlo G; City of Hope, Duarte, CA., Shah N; University California San Francisco, San Francisco, CA., Stadtmauer E; University of Pennsylvania, Philadelphia, PA., Vogl DT; University of Pennsylvania, Philadelphia, PA., Vesole DH; John Theurer Cancer Center, Hackensack, NJ., McCarthy PL; Roswell Park Comprehensive Cancer Center, Buffalo, NY., Hahn T; Roswell Park Comprehensive Cancer Center, Buffalo, NY.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2024 Aug 10; Vol. 42 (23), pp. 2757-2768. Date of Electronic Publication: 2024 May 03.

Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export.

Autor: Daneshmandi S; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Yan Q; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Choi JE; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Katsuta E; Department of Oncology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan., MacDonald CR; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Goruganthu M; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Roberts N; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Repasky EA; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Singh PK; Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Attwood K; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Wang J; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Landesman Y; Karyopharm Therapeutics, Newton, MA, USA., McCarthy PL; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Mohammadpour H; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. hemn.mohammadpour@roswellpark.org.

Publikováno v: Cellular & molecular immunology [Cell Mol Immunol] 2024 Aug; Vol. 21 (8), pp. 873-891. Date of Electronic Publication: 2024 Jun 20.

Galectin-3 predicts acute GvHD and overall mortality post reduced intensity allo-HCT: a BMT-CTN biorepository study.

Autor: McCarthy PL; Department of Medicine, Transplant and Cellular Therapy Program, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Attwood KM; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Liu X; Flow and Image Cytometry Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Chen GL; Department of Medicine, Transplant and Cellular Therapy Program, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX, USA.; Blood and Marrow Transplant Clinical Trials Network GVHD Study Committee, Milwaukee, WI, USA., Minderman H; Flow and Image Cytometry Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Alousi A; Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX, USA., Bashey A; Blood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA., Lowsky R; Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Miklos DB; Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Hansen J; Clinical Research Division, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA., Westervelt P; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA., Yanik G; Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, MI, USA., Waller EK; Bone Marrow and Stem Cell Transplant Center, Winship Cancer Institute, Emory University, Atlanta, GA, USA., Howard A; National Marrow Donor Program, Minneapolis, MN, USA., Blazar BR; Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN, USA., Wallace PK; Flow and Image Cytometry Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Reshef R; Blood and Marrow Transplant Clinical Trials Network GVHD Study Committee, Milwaukee, WI, USA.; Blood and Marrow Transplantation and Cell Therapy Program, Columbia University Irving Medical Center, New York, NY, USA., Horowitz MM; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Maziarz RT; Blood and Marrow Transplant and Cellular Therapy Program, Oregon Health Science University, Portland, OR, USA., Levine JE; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mohammadpour H; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. hemn.mohammadpour@roswellpark.org.

Publikováno v: Bone marrow transplantation [Bone Marrow Transplant] 2024 Mar; Vol. 59 (3), pp. 334-343. Date of Electronic Publication: 2023 Dec 18.

Shared graft-versus-leukemia minor histocompatibility antigens in DISCOVeRY-BMT.

Autor: Olsen KS; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Microbiology and Immunology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Jadi O; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Dexheimer S; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Bortone DS; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Vensko SP; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Bennett S; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Microbiology and Immunology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Tang H; College of Pharmacy, The Ohio State University, Columbus, OH., Diiorio M; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Saran T; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Dingfelder D; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Zhu Q; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY., Wang Y; Quantitative Sciences Unit, Department of Medicine, Stanford University, Palo Alto, CA., Haiman CA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA., Pooler L; The Center for Genetic Epidemiology, University of South California, Los Angeles, CA., Sheng X; Department of Preventive Medicine, University of Southern California, Los Angeles, CA., Webb A; Department of Biomedical Informatics, The Ohio State University, Columbus, OH., Pasquini MC; Center for International Blood and Marrow Transplant Research and Medical College of Wisconsin, Milwaukee, WI., McCarthy PL; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY., Spellman SR; National Marrow Donor Program, Center for International Blood and Marrow Transplant Research, Minneapolis, MN., Weimer E; Department of Pathology & Laboratory Medicine, UNC School of Medicine, Chapel Hill, NC., Hahn T; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY., Sucheston-Campbell L; College of Pharmacy, The Ohio State University, Columbus, OH.; College of Veterinary Medicine, The Ohio State University, Columbus, OH., Armistead PM; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Vincent BG; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Microbiology and Immunology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Computational Medicine Program, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Curriculum in Bioinformatics and Computational Biology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

Publikováno v: Blood advances [Blood Adv] 2023 May 09; Vol. 7 (9), pp. 1635-1649.