PKR downregulation prevents copper-induced synaptic dysfunction and cognitive impairment in a murine model of Wilson’s disease

Autor: Chenchen Xu, Songyang Liu, Nan Cheng, Yongsheng Han, Xinheng Wang

Publikováno v: Frontiers in Neuroscience, Vol 18 (2024)

Synaptic efficacy is critical for memory formation and consolidation. Accumulating evidence suggest that synapses are impaired during Wilson’s disease (WD), contributing to neuronal dysfunction and cognitive decline. WD is a prototypical condition

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PKR downregulation prevents copper-induced synaptic dysfunction and cognitive impairment in a murine model of Wilson's disease.

Autor: Xu C; Institute of Neurology, Anhui University of Chinese Medicine, Hefei, China.; The Affiliated Hospital of Institute of Neurology, Anhui University of Chinese Medicine, Hefei, China., Liu S; Institute of Neurology, Anhui University of Chinese Medicine, Hefei, China., Cheng N; Institute of Neurology, Anhui University of Chinese Medicine, Hefei, China.; The Affiliated Hospital of Institute of Neurology, Anhui University of Chinese Medicine, Hefei, China., Han Y; Institute of Neurology, Anhui University of Chinese Medicine, Hefei, China.; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, China., Wang X; Institute of Neurology, Anhui University of Chinese Medicine, Hefei, China.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2024 Nov 25; Vol. 18, pp. 1447304. Date of Electronic Publication: 2024 Nov 25 (Print Publication: 2024).