Zobrazeno 1 - 10
of 41
pro vyhledávání: '"PKN3"'
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 264-289 (2019)
Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes.
Externí odkaz:
https://doaj.org/article/a8150fc97bc04d568eba1811cd1a86f5
Autor:
Mohammad Behnam Rad, Sayed-Hamidreza Mozhgani, Mohadeseh Zarei Ghobadi, Farida Behzadian, Mahdieh Farzanehpour
Publikováno v:
Journal of Medical Virology. 91:2134-2141
The expression levels of many genes change after treatment of human immunodeficiency virus (HIV)-infected subjects by antiretroviral drugs. High-throughput analysis of tremendous datasets led to the discovery of genes that are implicated in the treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccad51cb6f177623ea16c2363e228009
https://doi.org/10.1002/jmv.25549
https://doi.org/10.1002/jmv.25549
Autor:
Lenka Koudelková, Daniel Rösel, Jakub Gemperle, Michal Dibus, Jan Brábek, Keziban Unsal-Kacmaz
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 264-289 (2019)
Gemperle, J, Dibus, M, Koudelkova, L, Rosel, D & Brabek, J 2019, ' The interaction of p130Cas with PKN3 promotes malignant growth ', Molecular Oncology, vol. 13, no. 2, pp. 264-289 . https://doi.org/10.1002/1878-0261.12401
Molecular Oncology
Gemperle, J, Dibus, M, Koudelkova, L, Rosel, D & Brabek, J 2019, ' The interaction of p130Cas with PKN3 promotes malignant growth ', Molecular Oncology, vol. 13, no. 2, pp. 264-289 . https://doi.org/10.1002/1878-0261.12401
Molecular Oncology
Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e162bd30a9b9601271224aed2e07a794
https://doaj.org/article/a8150fc97bc04d568eba1811cd1a86f5
https://doaj.org/article/a8150fc97bc04d568eba1811cd1a86f5
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7769, p 7769 (2020)
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7769, p 7769 (2020)
Protein kinase N3 (PKN3) is a serine/threonine kinase implicated in tumor progression of multiple cancer types, however, its substrates and effector proteins still remain largely understudied. In the present work we aimed to identify novel PKN3 subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ad711dfc1b53a9105698fd455de53e13
Autor:
Asquith Crm, David H. Drewry, Carrow I. Wells, Sinha P, Kwarcinski Fe, Zutshi R, Tuomo Laitinen, Julie E. Pickett, Graham J. Tizzard, Louisa Temme
The development of a small library of 4-anilinoquinolines led to the identification of 7-iodo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine 16 as a potent inhibitor of Protein Kinase Novel 3 (PKN3) with an IC50 of 1.3 μM in cells. Compound 16 presents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53ab4afff3c96be199df7ee7bbe88b3
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification
Autor:
Baishan Jiang, Zainab M. Doctor, Jared L. Johnson, Lewis C. Cantley, Tomer M. Yaron, Tinghu Zhang, Jarrod A. Marto, William M. Alexander, Sindhu Carmen Sivakumaren, Charles J. Murphy, Scott B. Ficarro, Nathanael S. Gray, Nicholas Kwiatkowski, Christopher M. Browne, Joseph D. Card
Publikováno v:
Journal of the American Chemical Society. 141:191-203
Despite recent clinical successes for irreversible drugs, potential toxicities mediated by unpredictable modification of off-target cysteines represents a major hurdle for expansion of covalent drug programs. Understanding the proteome-wide binding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b54ff682fc3884c846f37412aaa35c
https://doi.org/10.1021/jacs.8b07911
https://doi.org/10.1021/jacs.8b07911
Akademický článek
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Autor:
Gemperle, Jakub
The adaptor protein p130Cas (CAS, BCAR1) represents a nodal signaling platform for integrin and growth factor receptor signaling, and influences normal development and tissue homeostasis. Its altered expression drives many pathological conditions inc
Externí odkaz:
http://www.nusl.cz/ntk/nusl-391387
Autor:
Gemperle, Jakub
The adaptor protein p130Cas (CAS, BCAR1) represents a nodal signaling platform for integrin and growth factor receptor signaling, and influences normal development and tissue homeostasis. Its altered expression drives many pathological conditions inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d5cd20b0b7114e26acc2db0567697a94
http://www.nusl.cz/ntk/nusl-463336
http://www.nusl.cz/ntk/nusl-463336