Zobrazeno 1 - 10
of 19
pro vyhledávání: '"PKM2, pyruvate kinase M2"'
Autor:
Ping Yu Xiong, Lian Tian, Kimberly J. Dunham-Snary, Kuang-Hueih Chen, Jeffrey D. Mewburn, Monica Neuber-Hess, Ashley Martin, Asish Dasgupta, Francois Potus, Stephen L. Archer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2019)
Introduction: Group 2 pulmonary hypertension (PH), defined as a mean pulmonary arterial pressure ≥25 mmHg with elevated pulmonary capillary wedge pressure >15 mmHg, has no approved therapy and patients often die from right ventricular failure (RVF)
Externí odkaz:
https://doaj.org/article/a16e88c2eeca4250a705d66bd834b54e
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722d
https://doi.org/10.1016/j.apsb.2020.09.007
https://doi.org/10.1016/j.apsb.2020.09.007
Autor:
Hsin Ming Chen, Jeng Fan Lo, Ching Wen Chang, Yi Fen Chen, Tz Yu Kuo, Chung Ji Liu, Hao Yuan Chia, Chia Yi Chou, Pei Chun Huang, Tsai Ying Chen, Wan Chun Li, Lu Te Chuang, Yi Ta Hsieh, Jian Min Huang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 7, Pp 641-652 (2019)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate. Pyruvate is a main glycolytic metabolite that could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92754b6cd8bfc62335acf4065f363f43
https://doi.org/10.1016/j.neo.2019.04.007
https://doi.org/10.1016/j.neo.2019.04.007
Publikováno v:
Neoplasia (New York, N.Y.)
Despite the anti-proliferative and survival benefits from tumor treating fields (TTFields) in human glioblastoma (hGBM), little is known about the effects of this form of alternating electric fields therapy on the aberrant glycolysis of hGBM. [18F]FD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55400a6587dfd27f8ee013ff5e41d4d0
https://pubmed.ncbi.nlm.nih.gov/33221711
https://pubmed.ncbi.nlm.nih.gov/33221711
Publikováno v:
Chinese Journal of Cancer Research
Gastrointestinal (GI) cancer is one of the most common causes of cancer-related deaths worldwide. Tumor markers are valuable in detecting post-surgical recurrence or in monitoring response to chemotherapy. Pyruvate kinase isoform M2 (PKM2), a glycoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59836271bfafd42284a601e4451092c9
http://europepmc.org/articles/PMC6328500
http://europepmc.org/articles/PMC6328500
Autor:
William Yuan, Marcia C. Haigis, Alison E. Ringel, Samantha J. Wong, Joao A. Paulo, Haejin Yoon, Mark A. Currie
Publikováno v:
The Journal of Biological Chemistry
Since the discovery of the prolyl hydroxylases domain (PHD) proteins and their canonical hypoxia-inducible factor (HIF) substrate two decades ago, a number of in vitro hydroxylation (IVH) assays for PHD activity have been developed to measure the PHD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fbf41f03fef736ff3ca54873213228
https://doi.org/10.1016/j.jbc.2021.100397
https://doi.org/10.1016/j.jbc.2021.100397
Akademický článek
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Publikováno v:
Nutrition & Metabolism
Background Recent studies in animal models, based on the hypothesis that malignant glioma cells are more dependent on glycolysis for energy generation, have shown promising results using ketogenic diet (KD) therapy as an alternative treatment strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4112a8ae18625eabc21a984dd7c60b7f
https://doi.org/10.1186/1743-7075-10-47
https://doi.org/10.1186/1743-7075-10-47
Akademický článek
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Akademický článek
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