Zobrazeno 1 - 10
of 4 462
pro vyhledávání: '"PKM2"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 4497-4510 (2024)
Anni Zhao,1,* Xiaomei Liu,1,* Xiping Chen,1,* Sha Na,1,* Hui Wang,1 Xuan Peng,1 Peizhong Kong,1 Lu Li1,2 1Department of Biochemistry and Molecular Biology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese
Externí odkaz:
https://doaj.org/article/e4fe099d9f1348c78b426412194afce3
Publikováno v:
International Journal of COPD, Vol Volume 19, Pp 1905-1920 (2024)
Yang Liu,1 Lanxi Zhang,2 Jie Zhao,1,3 Ruilong Lu,1 Xuejie Shao,1 Kexin Xu,1 Jiansheng Li,1,3,4,* Yange Tian1,3,* 1Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan Province and Education Min
Externí odkaz:
https://doaj.org/article/fd69c7827aae44739c01ec6f2654d6de
Autor:
Jingru Guo, Junshu Nie, Dongni Li, Huaixiu Zhang, Tianrui Zhao, Shoufeng Zhang, Li Ma, Jingjing Lu, Hong Ji, Shize Li, Sha Tao, Bin Xu
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract NAD-dependent deacetylase Sirt2 is involved in mammalian metabolic activities, matching energy demand with energy production and expenditure, and is relevant to a variety of metabolic diseases. Here, we constructed Sirt2 knockout and adeno-a
Externí odkaz:
https://doaj.org/article/02f0a4ff9203471cb1b8eebc8e40105c
Autor:
Chaofan Peng, Peng Yang, Dongsheng Zhang, Chi Jin, Wen Peng, Tuo Wang, Qingyang Sun, Zhihao Chen, Yifei Feng, Yueming Sun
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2959-2976 (2024)
Excessive fructose diet is closely associated with colorectal cancer (CRC) progression. Nevertheless, fructose's specific function and precise mechanism in colorectal cancer liver metastasis (CRLM) is rarely known. Here, this study reported that the
Externí odkaz:
https://doaj.org/article/e671163b1cd34cb4ae3de4cbe636e46b
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 535-541 (2024)
Background: Ischaemic stroke can lead to many complications, but treatment options are limited. Icariin is a traditional Chinese medicine with reported neuroprotective effects against ischaemic cerebral injury; however, the underlying mechanisms by w
Externí odkaz:
https://doaj.org/article/10952d42ec3840258908148afe329e51
Autor:
Zhe Guo, Jinpeng Bai, Jun Wang, Xiuyuan Lang, Min-Min Cao, Si-Jia Zhong, Liang Cui, Yang Hu, Xiao-Yan Qin, Rongfeng Lan
Publikováno v:
Journal of Functional Foods, Vol 122, Iss , Pp 106526- (2024)
Microglia-mediated neuroinflammation and synaptic damage contribute to the pathogenesis of major depressive disorder. Coeloglossum viride var. bracteatum extract (CE) has anti-inflammatory and neuroprotective effects. Therefore, we hypothesized that
Externí odkaz:
https://doaj.org/article/ca5f569a5ccd4ff5acd99704c0e36718
Publikováno v:
Brain and Behavior, Vol 14, Iss 10, Pp n/a-n/a (2024)
ABSTRACT Introduction The presence of hypoxic‐ischemic brain damage (HIBD) in neonates triggers a strong neuroinflammatory reaction. Pyroptosis, a programmed cell death mechanism associated with inflammation, plays a crucial role in HIBD. Pyruvate
Externí odkaz:
https://doaj.org/article/b4edee36c7d04ee7b520a3bfbba82671
Publikováno v:
Translational Oncology, Vol 48, Iss , Pp 102004- (2024)
Circular RNAs (circRNAs) have been reported to be associated with the malignant phenotypes of cancer. However, the role and underlying mechanism of hsa_Circ_0008035 in colorectal cancer (CRC) remains unclear. In this study, we elucidated the pivotal
Externí odkaz:
https://doaj.org/article/35fd60d4f3d145228e9be4b83533c5c0
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 5023-5036 (2024)
Serine/arginine-rich splicing factors (SRSFs), part of the serine/arginine-rich (SR) protein family, play a crucial role in precursor RNA splicing. Abnormal expression of SRSFs in tumors can disrupt normal RNA splicing, contributing to tumor progress
Externí odkaz:
https://doaj.org/article/0cfd9e6a38004fecbc02928747737a19
Autor:
Cheng Qian, Yueke Zhou, Teng Zhang, Guanglu Dong, Mengyao Song, Yu Tang, Zhonghong Wei, Suyun Yu, Qiuhong Shen, Wenxing Chen, Jaesung P. Choi, Juming Yan, Chongjin Zhong, Li Wan, Jia Li, Aiyun Wang, Yin Lu, Yang Zhao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2077-2096 (2024)
Aberrant tumor blood vessels are prone to propel the malignant progression of tumors, and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor progression. Herei
Externí odkaz:
https://doaj.org/article/51ac35cb0c6e4b7dad8b83cb26c3968d