Zobrazeno 1 - 10
of 4 621
pro vyhledávání: '"PKM2"'
Publikováno v:
International Journal of COPD, Vol Volume 19, Pp 1905-1920 (2024)
Yang Liu,1 Lanxi Zhang,2 Jie Zhao,1,3 Ruilong Lu,1 Xuejie Shao,1 Kexin Xu,1 Jiansheng Li,1,3,4,* Yange Tian1,3,* 1Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan Province and Education Min
Externí odkaz:
https://doaj.org/article/fd69c7827aae44739c01ec6f2654d6de
Autor:
Jingru Guo, Junshu Nie, Dongni Li, Huaixiu Zhang, Tianrui Zhao, Shoufeng Zhang, Li Ma, Jingjing Lu, Hong Ji, Shize Li, Sha Tao, Bin Xu
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract NAD-dependent deacetylase Sirt2 is involved in mammalian metabolic activities, matching energy demand with energy production and expenditure, and is relevant to a variety of metabolic diseases. Here, we constructed Sirt2 knockout and adeno-a
Externí odkaz:
https://doaj.org/article/02f0a4ff9203471cb1b8eebc8e40105c
Autor:
Chaofan Peng, Peng Yang, Dongsheng Zhang, Chi Jin, Wen Peng, Tuo Wang, Qingyang Sun, Zhihao Chen, Yifei Feng, Yueming Sun
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2959-2976 (2024)
Excessive fructose diet is closely associated with colorectal cancer (CRC) progression. Nevertheless, fructose's specific function and precise mechanism in colorectal cancer liver metastasis (CRLM) is rarely known. Here, this study reported that the
Externí odkaz:
https://doaj.org/article/e671163b1cd34cb4ae3de4cbe636e46b
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 535-541 (2024)
Background: Ischaemic stroke can lead to many complications, but treatment options are limited. Icariin is a traditional Chinese medicine with reported neuroprotective effects against ischaemic cerebral injury; however, the underlying mechanisms by w
Externí odkaz:
https://doaj.org/article/10952d42ec3840258908148afe329e51
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 5023-5036 (2024)
Serine/arginine-rich splicing factors (SRSFs), part of the serine/arginine-rich (SR) protein family, play a crucial role in precursor RNA splicing. Abnormal expression of SRSFs in tumors can disrupt normal RNA splicing, contributing to tumor progress
Externí odkaz:
https://doaj.org/article/0cfd9e6a38004fecbc02928747737a19
Autor:
Cheng Qian, Yueke Zhou, Teng Zhang, Guanglu Dong, Mengyao Song, Yu Tang, Zhonghong Wei, Suyun Yu, Qiuhong Shen, Wenxing Chen, Jaesung P. Choi, Juming Yan, Chongjin Zhong, Li Wan, Jia Li, Aiyun Wang, Yin Lu, Yang Zhao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2077-2096 (2024)
Aberrant tumor blood vessels are prone to propel the malignant progression of tumors, and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor progression. Herei
Externí odkaz:
https://doaj.org/article/51ac35cb0c6e4b7dad8b83cb26c3968d
Autor:
Juan Zhang, Fan Ouyang, Anbo Gao, Tian Zeng, Ming Li, Hui Li, Wenchao Zhou, Qing Gao, Xing Tang, Qunfeng Zhang, Xiaomin Ran, Gang Tian, Xiyun Quan, Zhenzi Tang, Juan Zou, Yifei Zeng, Yunzhu Long, Yukun Li
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background The hypoxic tumor microenvironment is a key factor that promotes metabolic reprogramming and vascular mimicry (VM) in ovarian cancer (OC) patients. ESM1, a secreted protein, plays an important role in promoting proliferation and a
Externí odkaz:
https://doaj.org/article/a644082e6ecc4e72973a163b8952ca73
Autor:
Cristina Pagano, Laura Coppola, Giovanna Navarra, Giorgio Avilia, Beatrice Savarese, Giovanni Torelli, Sara Bruzzaniti, Erica Piemonte, Mario Galgani, Chiara Laezza, Maurizio Bifulco
Publikováno v:
FEBS Open Bio, Vol 14, Iss 5, Pp 843-854 (2024)
Glioblastoma (GBM) is a primary tumor in the central nervous system with poor prognosis. It exhibits elevated glucose uptake and lactate production. This metabolic state of aerobic glycolysis is known as the Warburg effect. N6‐isopentenyladenosine
Externí odkaz:
https://doaj.org/article/25482b0ce0d643bfb73c8b5ee7e24d93
CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Although papillary thyroid carcinoma (PTC) has a favorable prognosis, it could affect patient life quality and become a serious threat because of invasion and metastasis. Many investigations have suggested that circular RNAs (circ
Externí odkaz:
https://doaj.org/article/d5ab4fc5250e438981e0eaf715b0d0eb
Autor:
Chen Yurao, Fan Peng, Chen Zhenhai, Zheng Zemao, He Ming, Zhao Xiang, Chen Ronghuai, Yao Juan, Yang Zhaodong
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 2499-509 (2024)
Esophageal squamous cell carcinoma (ESCC), a highly aggressive subtype of esophageal cancer, is characterized by late-stage diagnosis and limited treatment options. Recent advancements in transcriptome sequencing technologies have illuminated the mol
Externí odkaz:
https://doaj.org/article/f3ae163288974f38ba258e07a8b9ccbf