Zobrazeno 1 - 10
of 116
pro vyhledávání: '"PKMζ"'
Publikováno v:
Brain Research Bulletin, Vol 217, Iss , Pp 111078- (2024)
Objective: The aim of this study is to elucidate the underlying mechanism through which glial cell line-derived neurotrophic factor (GDNF) improves cognitive deficits in adults resulting from neonatal surgical interventions. Methods: Newborn Sprague
Externí odkaz:
https://doaj.org/article/2ecf6ab93d8b4589939cefca349ee1eb
Autor:
Melissa C. Knouse, Alyssa R. Kniffin, Erin A. English, William Cuadrado, Troy M. Houser, Lisa A. Briand
Publikováno v:
Addiction Neuroscience, Vol 12, Iss , Pp 100169- (2024)
Opioid use disorder involves disruptions to glutamate homeostasis and dendritic spine density in the reward system. PKMζ is an atypical isoform of protein kinase C that is expressed exclusively in neurons and plays a role in postsynaptic glutamate s
Externí odkaz:
https://doaj.org/article/55979e128b5f4d09be87bb3b92ca3881
Autor:
Melissa C. Knouse, Andre U. Deutschmann, Miroslav N. Nenov, Mathieu E. Wimmer, Lisa A. Briand
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background Glutamate signaling within the nucleus accumbens underlies motivated behavior and is involved in psychiatric disease. Although behavioral sex differences in these processes are well-established, the neural mechanisms driving these
Externí odkaz:
https://doaj.org/article/b34a4c012d1f428cb0cf682f82d382fb
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/e5bf7e0ed6744f46819c95c5882bafb5
Autor:
Naveed Aslam
Publikováno v:
Frontiers in Systems Biology, Vol 2 (2023)
How can synaptic efficacies be maintained despite the fast turnover of proteins at synapses? Partially, we know that the synthesis of new proteins is essential for the induction of the late, long-lasting phase of long-term potentiation (L-LTP). Recen
Externí odkaz:
https://doaj.org/article/de0380cb465044d1a9d9ce4341e461db
Publikováno v:
Neuroscience Informatics, Vol 2, Iss 2, Pp 100050- (2022)
Objective: To investigate the molecular mechanism of enriched rehabilitation training in improving cognitive dysfunction of ischemic stroke.Material and method: We established a rat model of cerebral ischemia with cognitive impairment and then carrie
Externí odkaz:
https://doaj.org/article/6ed37cb16a7244a7bce592efb54a0534
Autor:
Jianfeng Liu
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The stress system in the brain plays a pivotal role in keeping humans and animals from harmful stimuli. However, excessive stress will cause maladaptive changes to the stress system and lead to depression. Despite the high prevalence of depression, t
Externí odkaz:
https://doaj.org/article/448e0bd5cbe44f6a8d25371eb0b81473
Autor:
Dongyang Cui, Xiaodong Jiang, Ming Chen, Huan Sheng, Da Shao, Li Yang, Xinli Guo, Yingqi Wang, Bin Lai, Ping Zheng
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Rac1 is a small GTPase of the Rho family. A previous study showed that the activation of Rac1 had an opposing effect on induction and maintenance of long-term potentiation (LTP) in the hippocampus. However, the molecular mechanism underlying this opp
Externí odkaz:
https://doaj.org/article/f5a93aee91754b5c87466dc7092a4a43