Zobrazeno 1 - 10
of 19
pro vyhledávání: '"PKD protein"'
Autor:
Dirkx, E.
Heart failure is one of the most common causes of death. The last few years, heart failure has been associated with metabolic changes. An example is the diabetic patient; this patient often suffers from heart problems because of too much fat absorpti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05cb81bd6f465caf29ad07f4cfda1ea
https://doi.org/10.26481/dis.20120203ed
https://doi.org/10.26481/dis.20120203ed
Publikováno v:
The Journal of Biological Chemistry
Tissue factor (TF) is the principal initiator of blood coagulation and is necessary for thrombosis. We previously reported that lysophosphatidic acid (LPA), a potent bioactive lipid, highly induces TF expression at the transcriptional level in vascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca7c6add83b99be0e20211c123598fdf
https://pubmed.ncbi.nlm.nih.gov/34478715
https://pubmed.ncbi.nlm.nih.gov/34478715
Autor:
David C. Gershlick, Danièle Stalder
In eukaryotic cells, protein sorting is a highly regulated mechanism important for many physiological events. After synthesis in the endoplasmic reticulum and trafficking to the Golgi apparatus, proteins sort to many different cellular destinations i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f35c58dc9f52ad95e343310270ecae
https://www.repository.cam.ac.uk/handle/1810/305722
https://www.repository.cam.ac.uk/handle/1810/305722
Publikováno v:
Biochemical Journal
Copper ATPases, in analogy with other members of the P-ATPase superfamily, contain a catalytic headpiece including an aspartate residue reacting with ATP to form a phosphoenzyme intermediate, and transmembrane helices containing cation-binding sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572b6f2b12885b81c43c0cf6c5762e15
http://europepmc.org/articles/PMC4179477
http://europepmc.org/articles/PMC4179477
Autor:
Friederike Cuello, Alexandra J. Candasamy, Elisabeth Ehler, Metin Avkiran, Elizabeth M. Kemp, Konstantina Stathopoulou, Robert S. Haworth
Publikováno v:
Biochemical Journal
PKD (protein kinase D) is a serine/threonine kinase implicated in multiple cardiac roles, including the phosphorylation of the class II HDAC5 (histone deacetylase isoform 5) and thereby de-repression of MEF2 (myocyte enhancer factor 2) transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702f96280bc2077b635da4d8e6835ae3
https://doi.org/10.1042/bj20131026
https://doi.org/10.1042/bj20131026
Publikováno v:
Progress in Lipid Research
The four mammalian phosphatidylinositol 4-kinases modulate inter-organelle lipid trafficking, phosphoinositide signalling and intracellular vesicle trafficking. In addition to catalytic domains required for the synthesis of PI4P, the phosphatidylinos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1925c406463d888b15c0bc96083f3e55
Autor:
Christina, Lutz-Nicoladoni, Lutz-Nicoladoni, Christina, Nikolaus, Thuille, Thuille, Nikolaus, Katarzyna, Wachowicz, Wachowicz, Katarzyna, Thomas, Gruber, Gruber, Thomas, Michael, Leitges, Leitges, Michael, Gottfried, Baier, Baier, Gottfried
Publikováno v:
Immunology Letters
Highlights ► Conventional PKCα and PKCβ isotypes have overlapping functions in T cell activation signalling. ► PKCα and PKCβ cooperate functionally to mediate IL-2 gene expression.
The physiological functions of PKCα and PKCθ isotypes
The physiological functions of PKCα and PKCθ isotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::62871523bb3d10affc6ead30811ad310
Autor:
María N. Navarro, Linda V. Sinclair, Rosemary G. Clarke, Doreen A. Cantrell, Carmen Feijoo-Carnero, Sharon A. Matthews
Publikováno v:
Biochemical Journal
PKD (protein kinase D) 2 is a serine/threonine kinase activated by diacylglycerol in response to engagement of antigen receptors in lymphocytes. To explore PKD2 regulation and function in TCR (T-cell antigen receptor) signal transduction we expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff87c68788eec64bba60505be3b2caf
https://doi.org/10.1042/bj20111700
https://doi.org/10.1042/bj20111700
Publikováno v:
Febs Letters
Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases. Hence, in PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2402f69a4cead978540c317883f8461f
https://doi.org/10.1016/j.febslet.2007.06.060
https://doi.org/10.1016/j.febslet.2007.06.060
Publikováno v:
Febs Letters
To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753fa4370ad18e90a740c60600be8d86
http://europepmc.org/articles/PMC1942070
http://europepmc.org/articles/PMC1942070