Zobrazeno 1 - 10
of 306
pro vyhledávání: '"PKC–protein kinase C"'
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Guhong injection (GHI) is a drug for ischemic stroke created by combining safflower, a traditional Chinese medicine, and aceglutamide, a Western medicine. In this study, we investigated the curative effect of GHI on cerebral ischemia–reperfusion (I
Externí odkaz:
https://doaj.org/article/9b63f50d74464378a0bde17afea5cb2a
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Human neutrophils express two unique antibody receptors for IgG, the FcγRIIa and the FcγRIIIb. FcγRIIa contains an immunoreceptor tyrosine-based activation motif (ITAM) sequence within its cytoplasmic tail, which is important for initiating signal
Externí odkaz:
https://doaj.org/article/7a3ab1ad901b4ba48ff7fb6b4abfb5a6
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 695-716 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Diarrhea is one of the most common illnesses and is often caused by bacterial infection. Recently, we have shown that human Na+/H+ exchanger NHE3 (hNHE3), but not non-human NHE3s, interacts with the E3 ubiquitin ligase Nedd4-2. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d39e72e4258b61df22d22d51d780ec
https://doi.org/10.1016/j.jcmgh.2021.11.006
https://doi.org/10.1016/j.jcmgh.2021.11.006
Autor:
Matías Bayley, María Inés Ragone, Soledad Inés Matera, Germán A. Colareda, María L. Flores, Osvaldo León Córdoba, Alicia E. Consolini
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 11, Iss 6, Pp 471-480 (2021)
Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine
Background and aim Phytoestrogens are traditionally used for cardiovascular risks but direct effects on the ischemic heart remain unclear. Plants with phytoestrogens are used for reducing menopausic symptoms and they could also be cardioprotectives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dae20a619016b466bd15c0b7134632a
http://www.sciencedirect.com/science/article/pii/S2225411021000365
http://www.sciencedirect.com/science/article/pii/S2225411021000365
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020
https://doi.org/10.1016/j.apsb.2020.12.020
Autor:
Joanne L. Mitchell, Jonathan M. Gibbins, Giordano Pula, Renato Simões Gaspar, Plinio Ferreira
Publikováno v:
Free Radical Biology & Medicine
Background Platelets release platelet-derived extracellular vesicles (PDEVs) upon activation – in a process that is regulated by generation of reactive oxygen species (ROS). Platelet NADPH oxidase-1 (Nox-1) contributes to ROS generation and thrombu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a940fc27fa7f66f039c947829a0f1f31
https://doi.org/10.1016/j.freeradbiomed.2021.01.051
https://doi.org/10.1016/j.freeradbiomed.2021.01.051
Autor:
Mingfei Ji, Jie Chen, Chuan Lv, Xinyi Li, Zongtao Chai, Jun Pu, Yuran Qiu, Duan Ni, Jian Zhang, Yuanhao Wang, Shaoyong Lu
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3433-3446 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3433-3446 (2021)
RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301d6dec04ce4d283571a3cfb861136b
http://europepmc.org/articles/PMC8642438
http://europepmc.org/articles/PMC8642438
Autor:
N.V. Vorobjeva
Publikováno v:
Moscow University Biological Sciences Bulletin
— Neutrophils are the “first line” of defense against pathogens in the locus of inflammation, where they use effector functions such as phagocytosis, degranulation, and formation of reactive oxygen species (ROS). In 2004, Artuto Zychlinsky char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01f41f8c5f92ac886ffa0590ea714b0
http://europepmc.org/articles/PMC7869772
http://europepmc.org/articles/PMC7869772
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722d
https://doi.org/10.1016/j.apsb.2020.09.007
https://doi.org/10.1016/j.apsb.2020.09.007
Autor:
Hitomi Imachi, Koji Murao, Tao Dong, Seisuke Sato, Huanxiang Zhang, Jingya Lyu, Toshihiro Kobayashi, Mari Matsumoto, Kensaku Fukunaga, Takanobu Saheki, Hisakazu Iwama
Publikováno v:
Molecular Metabolism, Vol 34, Iss, Pp 16-26 (2020)
Molecular Metabolism
Molecular Metabolism
Objective Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) influences hepatic cholesterol transportation. Accumulation of hepatic cholesterol leads to fatty liver disease, which is improved by glucagon-like peptide 1 (GLP-1) in di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300f09297dba2c83ad205f091614e019
http://www.sciencedirect.com/science/article/pii/S2212877820300016
http://www.sciencedirect.com/science/article/pii/S2212877820300016