Výsledky vyhledávání - "PKCα/β inhibitor"

Akademický článek

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Autor: Sharp, Thomas E., III ^a, Kubo, Hajime ^a, Berretta, Remus M. ^a, Starosta, Timothy ^b, Wallner, Markus ^a, Schena, Giana J. ^a, Hobby, Alexander R. ^a, Yu, Daohai ^c, Trappanese, Danielle M. ^a, George, Jon C. ^{a, d}, Molkentin, Jeffery D. ^e, Houser, Steven R. ^{a, ∗}

Publikováno v: In JACC: Basic to Translational Science December 2017 2(6):669-683

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Akademický článek

Is Protein Kinase C Inhibition the Tip of the Iceberg in New Therapeutics for Acutely Decompensated Heart Failure?∗

Autor: David R. Pimental, MD, Flora Sam, MD

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 684-687 (2017)

Externí odkaz: https://doaj.org/article/a56b111a11e0485ea694ff74d8114c5d

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Akademický článek

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Autor: Thomas E. Sharp, III, BA, Hajime Kubo, PhD, Remus M. Berretta, BS, Timothy Starosta, BS, Markus Wallner, MD, PhD, Giana J. Schena, BS, Alexander R. Hobby, BS, Daohai Yu, PhD, Danielle M. Trappanese, PhD, Jon C. George, MD, Jeffery D. Molkentin, PhD, Steven R. Houser, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 669-683 (2017)

Inotropic support is often required to stabilize the hemodynamics of patients with acute decompensated heart failure; while efficacious, it has a history of leading to lethal arrhythmias and/or exacerbating contractile and energetic insufficiencies.

Externí odkaz: https://doaj.org/article/dd3c3f7a8fed47668b3c56e6c1ad9062

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Akademický článek

Protein kinase Cα/β inhibitor Gö6976 promotes PC12 cell adhesion and spreading through membrane recruitment and activation of protein kinase Cδ

Autor: Youn Jung, Sung ^a, Bok Kim, O ^a, Kang, Hyun Ki ^a, Jang, Da Hyun ^a, Min, Byung-Moo ^{a, ⁎}, Yu, Frank H. ^{b, ⁎}

Publikováno v: In Experimental Cell Research 1 February 2013 319(3):153-160

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Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Autor: Giana Schena, Steven R. Houser, Danielle M. Trappanese, Daohai Yu, Jon C. George, Jeffery D. Molkentin, Hajime Kubo, Tim Starosta, Remus M. Berretta, Alexander R. Hobby, Markus Wallner, Thomas E. Sharp

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 669-683 (2017)
JACC: Basic to Translational Science

Visual Abstract
Highlights • Acute protein kinase A α (PKCα) inhibition with ruboxistaurin reduces heart size post-myocardial infarction. • Acute PKCα inhibition with ruboxistaurin increases contractility post-myocardial infarction. • P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6732927aa6f50eb927b8ed0bcd5b35c8
http://www.sciencedirect.com/science/article/pii/S2452302X17301559

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Editorial & Opinion

Is Protein Kinase C Inhibition the Tip of the Iceberg in New Therapeutics for Acutely Decompensated Heart Failure?

Autor: Pimental, David R. ^{a, b, c}, Sam, Flora ^{a, b, c, ∗}

Publikováno v: In JACC: Basic to Translational Science December 2017 2(6):684-687

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